مورد إلكتروني
Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester.
| العنوان: | Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester. |
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| المصدر: | International Journal of Molecular Medicine, 5 (1 |
| بيانات النشر: | 2000-01 |
| تفاصيل مُضافة: | Ladrière, Laurence Björkling, Fredrik Malaisse, Willy |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Hereditarily diabetic Goto-Kakizaki rats were infused for 5 min with saline, containing as required nateglinide or mixed molecules (HD154 and HD166) with both a nateglinide moiety and a succinic acid ester moiety. The dose of these agents given intravenously amounted to 5.0 nmol/g body weight in all cases. All agents provoked a comparable early increase in plasma insulin concentration. However, HD154 and HD166, but not nateglinide itself, also caused a secondary rise in plasma insulin concentration 30 min after their infusion. It is proposed that mixed molecules formed of both a hypoglycemic sulfonylurea or meglitinide analog and a succinic acid ester may be better able than the antidiabetic agents themselves to evoke a sustained stimulation of insulin release in non-insulin-dependent diabetes. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Sciences bio-médicales et agricoles, Animals, Cyclohexanes -- chemistry, Cyclohexanes -- pharmacology, Diabetes Mellitus -- genetics, Hypoglycemic Agents -- chemistry, Hypoglycemic Agents -- pharmacology, Insulin -- blood, Molecular Structure, Phenylalanine -- analogs & derivatives, Phenylalanine -- chemistry, Phenylalanine -- pharmacology, Rats, Rats, Inbred Strains, Succinates -- chemistry, Succinates -- pharmacology, Time Factors, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | No full-text files English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/50572 uri/info:pmid/10601576 uri/info:scp/0033630749 1363712292 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1363712292 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |