مورد إلكتروني
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
| العنوان: | EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. |
|---|---|
| المصدر: | Cell, 115 (5 |
| بيانات النشر: | 2003-11 |
| تفاصيل مُضافة: | Hughes-Davies, L Huntsman, David Ruas, Margarida Fuks, François Bye, Jacqueline Chin, Suet-Feung Milner, J Brown, Lindsay A Hsu, Forrest Gilks, Blake Nielsen, Torsten Schulzer, Michael Chia, Stephen Ragaz, Joseph Cahn, Anthony Linger, Lori Ozdag, Hilal Cattaneo, Elena Jordanova, E S Schuuring, Edward Yu, David S Venkitaraman, Ashok Ponder, Bruce Doherty, Aidan Aparicio, Samuel Bentley, David Theillet, Charles Ponting, Chris P Caldas, Carlos Kouzarides, Tony |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DNA repair and transcriptional regulation. Here we identify a protein, EMSY, which binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1beta and BS69, and localizes to sites of repair following DNA damage. EMSY maps to chromosome 11q13.5, a region known to be involved in breast and ovarian cancer. We show that the EMSY gene is amplified almost exclusively in sporadic breast cancer (13%) and higher-grade ovarian cancer (17%). In addition, EMSY amplification is associated with worse survival, particularly in node-negative breast cancer, suggesting that it may be of prognostic value. The remarkable clinical overlap between sporadic EMSY amplification and familial BRCA2 deletion implicates a BRCA2 pathway in sporadic breast and ovarian cancer. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Sciences bio-médicales et agricoles, BRCA2 Protein -- deficiency, BRCA2 Protein -- genetics, Base Sequence -- genetics, Breast Neoplasms -- genetics, Breast Neoplasms -- metabolism, Carcinoma -- genetics, Carcinoma -- metabolism, Carrier Proteins -- genetics, Chromosomal Proteins, Non-Histone -- genetics, Chromosomes, Human, Pair 11 -- genetics, DNA, Complementary -- analysis, DNA, Complementary -- genetics, Exons -- genetics, Female, Gene Amplification -- genetics, Gene Silencing -- physiology, Genes, Regulator -- genetics, Genetic Predisposition to Disease -- genetics, Humans, Molecular Sequence Data, Neoplasm Proteins, Nuclear Proteins, Ovarian Neoplasms -- genetics, Ovarian Neoplasms -- metabolism, Phylogeny, Plant Proteins -- genetics, Prognosis, Protein Structure, Tertiary -- genetics, Repressor Proteins -- genetics, Repressor Proteins -- isolation & purification, Signal Transduction, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | No full-text files English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/50451 uri/info:pii/S0092867403009309 uri/info:pmid/14651845 1363713368 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1363713368 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |