مورد إلكتروني
Acute Trypanosoma cruzi infection: IL-12, IL-18, TNF, sTNFR and NO in T. rangeli-vaccinated mice.
| العنوان: | Acute Trypanosoma cruzi infection: IL-12, IL-18, TNF, sTNFR and NO in T. rangeli-vaccinated mice. |
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| المصدر: | Vaccine, 22 (15-16 |
| بيانات النشر: | 2004-05 |
| تفاصيل مُضافة: | Basso, B Cervetta, L Moretti, E Carlier, Yves Truyens, Carine |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | We have developed an experimental model of vaccination against the infection with the protozoa Trypanosoma cruzi, the agent of Chagas disease in Latin America. Vaccination was performed with Trypanosoma rangeli, a non-pathogenic protozoa sharing many antigens with T. cruzi. It strongly protected BALB/c mice, sharply reducing parasitaemia and mortality rate of the acute T. cruzi infection. The aim of the present work was to complete our previous study on the production of IFN-gamma and IL-10 in this vaccination model by investigating the production of IL-12p35 and p40, IL-18, TNF, TNF soluble receptors (sTNFR), and nitric oxide (NO), factors known to play a key role in the outcome of T. cruzi infection. We show that the protection obtained against the acute T. cruzi infection was surprisingly associated with reduced circulating levels of IL-18 and NO, whereas the release of IL-12p40 was enhanced in comparison to non-vaccinated infected animals. IL-12p35 remained undetectable in infected animals, vaccinated or not. The balance between sTNFR and TNF suggested a decrease of TNF bioactivity in vaccinated mice. These results show that the protection induced by the vaccination with T. rangeli against a challenging infection with T. cruzi is not associated with the strong type 1 immune response usually involved in the control of intracellular pathogens, particularly questioning the protective role of NO during the acute phase of T. cruzi infection. Journal Article Research Support, Non-U.S. Gov't SCOPUS: ar.j info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Sciences bio-médicales et agricoles, Animals, Chagas Disease -- immunology, Chagas Disease -- prevention & control, Cytokines -- biosynthesis, Interleukin-12 -- biosynthesis, Interleukin-18 -- biosynthesis, Mice, Mice, Inbred BALB C, Nitric Oxide -- biosynthesis, Protozoan Vaccines -- immunology, Receptors, Tumor Necrosis Factor -- biosynthesis, Survival Analysis, Trypanosoma -- immunology, Trypanosoma cruzi -- immunology, Tumor Necrosis Factor-alpha -- biosynthesis, Vaccination, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الإتاحة: | Open access content. Open access content 1 full-text file(s): info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | 1 full-text file(s): application/pdf English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/50740 uri/info:doi/10.1016/j.vaccine.2003.11.013 uri/info:pii/S0264410X0300803X uri/info:pmid/15121297 uri/info:scp/2342455199 1363713563 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1363713563 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |