مورد إلكتروني
The stimulus-secretion coupling of glucose-induced insulin release. XLII. Effects of extracellular pH on insulin release: their dependency on nutrient concentration.
| العنوان: | The stimulus-secretion coupling of glucose-induced insulin release. XLII. Effects of extracellular pH on insulin release: their dependency on nutrient concentration. |
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| المصدر: | Hormone and Metabolic Research, 12 (7 |
| بيانات النشر: | 1980-07 |
| تفاصيل مُضافة: | Hutton, J C Sener, Abdullah Herchuelz, André Valverde, Isabel Boschero, Antonio Carlos Malaisse, Willy |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Changes in extracellular pH affected insulin output from pancreatic islets stimulated with either glucose or alpha-ketoisocaproate. The extracellular pH at which the highest secretory response occurred was not identical in all cases, being shifted to alkaline values as the concentration of the nutrient secretagogue was increased. The output of insulin correlated with the nutrient-induced increment in 45Ca net uptake, but not with the rate of nutrient oxidation. By reference to changes in intracellular pH observed in islets exposed to either acidic media or increasing concentrations of alpha-ketoisocaproate, and taking into account a titration curve for the buffering capacity of islet homogenates, the optimal intracellular pH for insulin release was found to approximate a value of 0.09 pH unit below basal pH. It is postulated that, in the process of nutrient-induced insulin release, modest changes in intracellular pH participate in the multifactorial coupling between metabolic, ionic and secretory events. In Vitro Journal Article info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Sciences bio-médicales et agricoles, Animals, Calcium -- metabolism, Dose-Response Relationship, Drug, Female, Glucose -- metabolism, Glucose -- pharmacology, Hydrogen-Ion Concentration, Insulin -- secretion, Islets of Langerhans -- metabolism, Keto Acids -- pharmacology, Oxidation-Reduction, Perfusion, Rats, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
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| الإتاحة: | Open access content. Open access content |
| ملاحظة: | No full-text files English |
| أرقام أخرى: | EQY oai:dipot.ulb.ac.be:2013/62266 uri/info:doi/10.1055/s-2007-996274 uri/info:pmid/6995249 1363723647 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1363723647 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |