مورد إلكتروني
Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data
| العنوان: | Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data |
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| المصدر: | Research outputs 2022 to 2026 |
| بيانات النشر: | Edith Cowan University, Edith Cowan University, Research Online, Perth, Western Australia, Perth, Western Australia 2022-04-01T07:00:00Z |
| تفاصيل مُضافة: | van Gysen, Kirsten Kneebone, Andrew Le, Andrew Wu, Kenny Haworth, Annette Bromley, Regina Hruby, George O'Toole, James Booth, Jeremy Brown, Chris Pearse, Maria Sidhom, Mark Wiltshire, Kirsty Tang, Colin Eade, Thomas |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background and purpose: Poor quality radiotherapy can detrimentally affect outcomes in clinical trials. Our purpose was to explore the potential of knowledge-based planning (KBP) for quality assurance (QA) in clinical trials. Materials and methods: Using 30 in-house post-prostatectomy radiation treatment (PPRT) plans, an iterative KBP model was created according to the multicentre clinical trial protocol, delivering 64 Gy in 32 fractions. KBP was used to replan 137 plans. The KB (knowledge based) plans were evaluated for their ability to fulfil the trial constraints and were compared against their corresponding original treatment plans (OTP). A second analysis between only the 72 inversely planned OTPs (IP-OTPs) and their corresponding KB plans was performed. Results: All dose constraints were met in 100% of KB plans versus 69% of OTPs. KB plans demonstrated significantly less variation in PTV coverage (Mean dose range: KB plans 64.1 Gy-65.1 Gy vs OTP 63.1 Gy-67.3 Gy, p < 0.01). KBP resulted in significantly lower doses to OARs. Rectal V60Gy and V40Gy were 17.7% vs 27.7% (p < 0.01) and 40.5% vs 53.9% (p < 0.01) for KB plans and OTP respectively. Left femoral head (FH) V45Gy and V35Gy were 0.4% vs 7.4% (p < 0.01) and 7.9% vs 34.9% (p < 0.01) respectively. In the second analysis plan improvements were maintained. Conclusions: KBP created high quality PPRT plans using the data from a multicentre clinical trial in a single optimisation. It is a powerful tool for utilisation in clinical trials for patient specific QA, to reduce dose to surrounding OARs and variations in plan quality which could impact on clinical trial outcomes. |
| مصطلحات الفهرس: | Knowledge-based planning, Post-prostatectomy radiation therapy, Quality assurance, TROG 08.03, Diseases, Medicine and Health Sciences, text |
| URL: | |
| الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by-nc-nd/4.0 |
| ملاحظة: | application/pdf Research outputs 2022 to 2026 |
| أرقام أخرى: | ER0 oai:ro.ecu.edu.au:ecuworks2022-2026-1941 https://ro.ecu.edu.au/ecuworks2022-2026/941 info:doi/10.1016/j.phro.2022.05.004 https://ro.ecu.edu.au/context/ecuworks2022-2026/article/1941/viewcontent/Evaluating_20the_20utility_20of_20knowledge_based_20planning_20for_20clinical_20trials_20using_20the_20TROG_2008.03.pdf 1366764977 |
| المصدر المساهم: | EDITH COWAN UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1366764977 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |