مورد إلكتروني
Structural and functional effects of endometrial photodynamic therapy in a rat model.
| العنوان: | Structural and functional effects of endometrial photodynamic therapy in a rat model. |
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| المؤلفون: | Fehr, MK |
| المصدر: | American journal of obstetrics and gynecology; vol 175, iss 1, 115-121; 0002-9378 |
| بيانات النشر: | eScholarship, University of California 1996-07-01 |
| تفاصيل مُضافة: | Fehr, MK Tromberg, BJ Svaasand, LO Ngo, P Berns, MW Tadir, Y |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | ObjectiveOur purpose was to determine the optical dose required for irreversible endometrial destruction and prevention of implantation by photodynamic therapy with topical 5-aminolevulinic acid.Study designThree hours after drug application 74 female Sprague-Dawley rats received varying doses of 630 nm of light delivered by an intrauterine cylindric diffusing fiber.ResultsA 64 J/cm2 in situ optical dose resulted in long-term irreversible endometrial destruction; 43 J/cm2 damaged endometrial stroma and myometrium but not glandular epithelium 1 day after photodynamic therapy. At this lower light dose endometrium regenerated to full thickness within 3 weeks; however, implantation sacs were significantly reduced.ConclusionsPhotodynamic destruction of glandular epithelium accompanies irreversible endometrial ablation, whereas isolated stromal damage leads to reproductive impairment only. The optical dose required for endometrial ablation is approximately 1.5-fold higher than for reproductive impairment (functional damage) because of differential cell photosensitivity. |
| مصطلحات الفهرس: | Endometrium, Animals, Rats, Sprague-Dawley, Fibrosis, Necrosis, Edema, Aminolevulinic Acid, Photosensitizing Agents, Embryo Implantation, Time Factors, Female, Male, photodynamic threshold, optical dose, 5-aminolevulinic acid, protoporphyrin IX, rat model, Obstetrics & Reproductive Medicine, Paediatrics and Reproductive Medicine, article |
| URL: | |
| الإتاحة: | Open access content. Open access content CC-BY |
| ملاحظة: | application/pdf American journal of obstetrics and gynecology vol 175, iss 1, 115-121 0002-9378 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt7pg5m4j3 qt7pg5m4j3 https://escholarship.org/uc/item/7pg5m4j3 https://escholarship.org/ 1367522752 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1367522752 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |