مورد إلكتروني
Novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces
العنوان: | Novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces |
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بيانات النشر: | Basel : MDPI AG 2018 |
تفاصيل مُضافة: | Korzhikov-Vlakh, Viktor Averianov, Ilia Sinitsyna, Ekaterina Nashchekina, Yuliya Polyakov, Dmitry Guryanov, Ivan Lavrentieva, Antonina Raddatz, Lukas Korzhikova-Vlakh, Evgenia Scheper, Thomas Tennikova, Tatiana |
نوع الوثيقة: | Electronic Resource |
مستخلص: | To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly("-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-D-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands ("self-peptide" or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems. |
مصطلحات الفهرس: | Biofunctionalization, Bioligands, Cells adhesion, Nanoparticles for drug delivery, PCL, Phagocytosis, PLA, Polyesters, Polyvinylsaccharide, Scaffolds for bone tissue engineering, Antigen-antibody reactions, Biocompatibility, Biomimetics, Bone, Cell adhesion, Cell engineering, Controlled drug delivery, Hydrophilicity, Nanoparticles, Peptides, Scaffolds (biology), Targeted drug delivery, Tissue, Bone tissue engineering, Biomimetic materials, Article, Text |
URL: | Polymers 10 (2018), Nr. 12 2073-4360 |
الإتاحة: | Open access content. Open access content https://creativecommons.org/licenses/by/4.0 CC BY 4.0 Unported |
ملاحظة: | English |
أرقام أخرى: | DELUH oai:www.repo.uni-hannover.de:123456789/4331 Korzhikov-Vlakh, V.; Averianov, I.; Sinitsyna, E.; Nashchekina, Y.; Polyakov, D. et al.: Novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces. In: Polymers 10 (2018), Nr. 12, 1299. DOI: https://doi.org/10.3390/polym10121299 1372066897 |
المصدر المساهم: | LEIBNIZ UNIVERSIT From OAIster®, provided by the OCLC Cooperative. |
رقم الأكسشن: | edsoai.on1372066897 |
قاعدة البيانات: | OAIster |
الوصف غير متاح. |