مورد إلكتروني
Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema
| العنوان: | Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema |
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| المصدر: | Du , T , Mestre , H , Kress , B T , Liu , G , Sweeney , A M , Samson , A J , Rasmussen , M K , Mortensen , K N , Bork , P A R , Peng , W , Olveda , G E , Bashford , L , Toro , E R , Tithof , J , Kelley , D H , Thomas , J H , Hjorth , P G , Martens , E A , Mehta , R I , Hirase , H , Mori , Y & Nedergaard , M 2022 , ' Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema ' , Brain , vol. 145 , no. 2 , pp. 787–797 . |
| بيانات النشر: | 2022 |
| تفاصيل مُضافة: | Du, Ting Mestre, Humberto Kress, Benjamin T Liu, Guojun Sweeney, Amanda M Samson, Andrew J Rasmussen, Martin Kaag Mortensen, Kristian Nygaard Bork, Peter A R Peng, Weiguo Olveda, Genaro E Bashford, Logan Toro, Edna R Tithof, Jeffrey Kelley, Douglas H Thomas, John H Hjorth, Poul G Martens, Erik A Mehta, Rupal I Hirase, Hajime Mori, Yuki Nedergaard, Maiken |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Cerebral edema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that edema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of cerebrospinal fluid (CSF). Edema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of edema. Edema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of edema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral edema formation after cardiac arrest. |
| مصطلحات الفهرس: | Anoxic cerebral edema, Cardiac arrest, Cerebrospinal fluid, Spreading depolarizations, article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | EDN oai:pure.atira.dk:publications/c03774a5-4dfc-4916-8b5b-5353b4c790dd 1372614721 |
| المصدر المساهم: | TECHNICAL KNOWLEDGE CTR DENMARK From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1372614721 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |