مورد إلكتروني
A New Osteogenic Membrane to Enhance Bone Healing: At the Crossroads between the Periosteum, the Induced Membrane, and the Diamond Concept
| العنوان: | A New Osteogenic Membrane to Enhance Bone Healing: At the Crossroads between the Periosteum, the Induced Membrane, and the Diamond Concept |
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| المصدر: | Bioengineering, Vol. 10, no.2, p. 143 [1-22] (2023) |
| بيانات النشر: | MDPI AG 2023 |
| تفاصيل مُضافة: | UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation UCL - SSS/IREC/MORF - Pôle de Morphologie UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab UCL - SST/IMCN/BSMA - Bio and soft matter UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur UCL - (SLuc) Service de chirurgie et transplantation abdominale UCL - (SLuc) Service de chirurgie plastique Manon, Julie Evrard, Robin Fievé, Lies Bouzin, Caroline Magnin, Delphine Xhema, Daela Darius, Tom Bonaccorsi Riani, Eliano Gianello, Pierre Docquier, Pierre-Louis Schubert, Thomas Lengelé, Benoît Behets Wydemans, Catherine Cornu, Olivier |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The lack of viability of massive bone allografts for critical-size bone defect treatment remains a challenge in orthopedic surgery. The literature has reviewed the advantages of a multi-combined treatment with the synergy of an osteoconductive extracellular matrix (ECM), osteogenic stem cells, and growth factors (GFs). Questions are still open about the need for ECM components, the influence of the decellularization process on the latter, the related potential loss of function, and the necessity of using pre-differentiated cells. In order to fill in this gap, a bone allograft surrounded by an osteogenic membrane made of a decellularized collagen matrix from human fascia lata and seeded with periosteal mesenchymal stem cells (PMSCs) was analyzed in terms of de-/recellularization, osteogenic properties, PMSC self-differentiation, and angiogenic potential. While the decellularization processes altered the ECM content differently, the main GF content was decreased in soft tissues but relatively increased in hard bone tissues. The spontaneous osteogenic differentiation was necessarily obtained through contact with a mineralized bone matrix. Trying to deepen the knowledge on the complex matrix–cell interplay could further propel these tissue engineering concepts and lead us to provide the biological elements that allow bone integration in vivo. |
| مصطلحات الفهرس: | Bioengineering, Osteogenic membrane, Periosteal mesenchymal stem cells, Bone allograft, Decellularization, Cell–matrix interplay, In vitro model for bone regeneration, info:eu-repo/semantics/article |
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| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | English |
| أرقام أخرى: | UCDLC oai:dial.uclouvain.be:boreal:272593 boreal:272593 info:doi/10.3390/bioengineering10020143 urn:EISSN:2306-5354 1372920901 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1372920901 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |