مورد إلكتروني
The Impact of Sex on the Outcomes of Prosthetic Joint Infection Treatment with Debridement, Antibiotics and Implant Retention: A Systematic Review and Individual Patient Data Meta-analysis.
| العنوان: | The Impact of Sex on the Outcomes of Prosthetic Joint Infection Treatment with Debridement, Antibiotics and Implant Retention: A Systematic Review and Individual Patient Data Meta-analysis. |
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| المؤلفون: | Choong, AL, Shadbolt, C, Choong, E, Spelman, T, Muñoz-Mahamud, E, Lora-Tamayo, J, Kim, K, Wouthuyzen-Bakker, M, Spangehl, M, Chayakulkeeree, M, Young, SW, Choong, PFM, Dowsey, MM |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) 2022-11-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND: The influence of sex on the failure of débridement antibiotics and implant retention (DAIR) for treating prosthetic joint infection (PJI) is important for decision-making, patient counseling, and equitable health care. However, very few studies in the orthopaedic literature conduct sex-specific analyses. AIM: The primary aim was to determine whether sex influences treatment success after DAIR. METHODS: A systematic review and individual patient data (IPD) meta-analysis was conducted. MEDLINE (Ovid), EMBASE (Ovid), Web of Science, and Google Scholar were searched, and IPD was requested via e-mail. Patients who underwent DAIR after developing PJI within 12 months of a primary total hip or knee arthroplasty were included in the analysis. Treatment failure was defined by the Delphi International Consensus criteria. Adjusted odds ratios for treatment failure were calculated using a mixed-effects logistic regression. RESULTS: The study collected and analyzed IPD of 1,116 patients from 21 cohorts. The odds of treatment failure were 29% lower in women (odds ratio, 0.71; 95% CI 0.54 to 0.017; P = 0.017), after adjusting for duration of symptoms >7 days and Staphylococcus aureus infection (methicillin-susceptible Staphylococcus aureus or any infection with S aureus). None of the 64 studies included in the systematic review conducted a sex-specific analysis. CONCLUSION: For patients who developed a PJI within 1 year postsurgery, females have lower odds of DAIR failure than males. Other factors also have varying effects on outcome for men and women. It is essential to implement sex-specific analysis in orthopaedic research. |
| مصطلحات الفهرس: | Journal Article |
| URL: | NHMRC/1122526 NHMRC/1154203 |
| الإتاحة: | Open access content. Open access content CC BY https://creativecommons.org/licenses/by/4.0 |
| أرقام أخرى: | UMV oai:jupiter.its.unimelb.edu.au:11343/325351 Choong, A. L., Shadbolt, C., Choong, E., Spelman, T., Muñoz-Mahamud, E., Lora-Tamayo, J., Kim, K., Wouthuyzen-Bakker, M., Spangehl, M., Chayakulkeeree, M., Young, S. W., Choong, P. F. M. & Dowsey, M. M. (2022). The Impact of Sex on the Outcomes of Prosthetic Joint Infection Treatment with Debridement, Antibiotics and Implant Retention: A Systematic Review and Individual Patient Data Meta-analysis.. J Am Acad Orthop Surg Glob Res Rev, 6 (11), pp.e22.00102-. https://doi.org/10.5435/JAAOSGlobal-D-22-00102. 10.5435/JAAOSGlobal-D-22-00102 2474-7661 2474-7661 1373007205 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1373007205 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |