مورد إلكتروني
Sodium glucose cotransporter 2 inhibition in the diabetic kidney: an update.
| العنوان: | Sodium glucose cotransporter 2 inhibition in the diabetic kidney: an update. |
|---|---|
| المؤلفون: | Novikov, Aleksandra |
| المصدر: | Current opinion in nephrology and hypertension; vol 25, iss 1, 50-58; 1062-4821 |
| بيانات النشر: | eScholarship, University of California 2016-01-01 |
| تفاصيل مُضافة: | Novikov, Aleksandra Vallon, Volker |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Purpose of reviewThe sodium glucose cotransporter 2 (SGLT2) reabsorbs most of the glucose filtered by the kidneys. SGLT2 inhibitors reduce glucose reabsorption, thereby lowering blood glucose levels, and have been approved as new antihyperglycemic drugs. Although the therapeutic strategy is very promising, many questions remain.Recent findingsUsing validated antibodies, SGLT2 expression was localized to the brush border of the early proximal tubule in the human kidney and was found upregulated in genetic murine models of type 1 and 2 diabetes. SGLT2 may functionally interact with the Na/H exchanger NHE3 in the proximal tubule. SGLT1-mediated reabsorption explains the fractional renal glucose reabsorption of 40-50% during SGLT2 inhibition. SGLT2 is expressed on pancreatic alfa cells where its inhibition induces glucagon secretion. SGLT2 inhibition lowers glomerular filtration rate in hyperfiltering diabetic patients consistent with the tubular hypothesis of diabetic hyperfiltration. New data indicate a potential of SGLT2 inhibition for renal medullary hypoxia and ketoacidosis, but also for blood glucose effect-dependent and independent nephroprotective actions, renal gluconeogenesis inhibition, reduction in cardiovascular mortality, and cancer therapy.SummaryThe findings expand and refine our understanding of SGLT2 and its inhibition, have relevance for clinical practice, and will help interpret ongoing clinical trials on the long-term safety and cardiovascular effects of SGLT2 inhibitors. |
| مصطلحات الفهرس: | Kidney, Kidney Tubules, Proximal, Animals, Humans, Diabetic Nephropathies, Cardiovascular Diseases, Hypertension, Glucose, Blood Glucose, Glomerular Filtration Rate, Gluconeogenesis, Sodium-Glucose Transporter 2, Sodium-Glucose Transporter 2 Inhibitors, Cardiovascular, Kidney Disease, Diabetes, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Metabolic and endocrine, Renal and urogenital, Good Health and Well Being, diabetic kidney disease, glucose transport, glycemic control, sodium glucose cotransporter 2 inhibition, Clinical Sciences, Urology & Nephrology, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Current opinion in nephrology and hypertension vol 25, iss 1, 50-58 1062-4821 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt7rj4r1pn qt7rj4r1pn https://escholarship.org/uc/item/7rj4r1pn https://escholarship.org/ 1377970798 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1377970798 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |