مورد إلكتروني
Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer
| العنوان: | Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer |
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| المؤلفون: | Zhao,Mei, Fu,Lijuan, Xu,Panling, Wang,Ting, Li,Ping |
| بيانات النشر: | Dove Press 2023-03-23 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Mei Zhao,1,2 Lijuan Fu,1,2 Panling Xu,1,2 Ting Wang,1,2 Ping Li1,2 1Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Peopleâs Republic of China; 2Department of Integrated Traditional Chinese and Western Medicine, Anhui Medical University, Hefei, Peopleâs Republic of ChinaCorrespondence: Ping Li, Department of Chinese Integrative Medicine Oncology, The First Affiliated Hospital of Anhui Medical University, No. 120 Wanshui Road, Hefei, 230032, Anhui, Peopleâs Republic of China, Email liping1964@ahmu.edu.cnPurpose: Kanglaite injection (KLTi), made of Coix seed oil, has been shown to be effective in the treatment of numerous cancers. However, the anticancer mechanism requires further exploration. This study aimed to investigate the underlying anticancer mechanisms of KLTi in triple-negative breast cancer (TNBC) cells.Methods: Public databases were searched for active compounds in KLTi, their potential targets and TNBC-related targets. KLTiâs core targets and signaling pathways were determined through compound-target network, proteinâprotein interaction (PPI) network, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Molecular docking was carried out to predict the binding activity between active ingredients and key targets. In vitro experiments were conducted to further validate the predictions of network pharmacology.Results: Fourteen active components of KLTi were screened from the database. Fifty-three candidate therapeutic targets were selected, and bioinformatics analysis was performed to identify the top two active compounds and three core targets. GO and KEGG enrichment analyses indicated that KLTi exerts therapeutic effects on TNBC through the cell cycle pathway. Molecular docking results showed that the main compounds of KLTi exhibited good binding activity to key target proteins. Results from in vitro experiments showed that KLTi inh |
| مصطلحات الفهرس: | Drug Design, Development and Therapy, Original Research, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/doi/10.2147/DDDT.S397969 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | text/html English |
| أرقام أخرى: | NZDMP oai:dovepress.com/82488 1379074356 |
| المصدر المساهم: | DOVE MEDL PRESS LTD From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1379074356 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |