مورد إلكتروني
Melanoma stem cells promote metastasis via exosomal miR-1268a inactivation of autophagy
| العنوان: | Melanoma stem cells promote metastasis via exosomal miR-1268a inactivation of autophagy |
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| المصدر: | Biological Research v.55 2022 |
| بيانات النشر: | Sociedad de Biología de Chile 2022-01-01 |
| تفاصيل مُضافة: | Li,Xiaoshuang Liu,Doudou Chen,Hao Zeng,Bin Zhao,Qiting Zhang,Yuhan Chen,Yuting Wang,Jianyu Xing,H. Rosie |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Metastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the underlying mechanisms remain elusive. Communication between cancer stem cells (CSCs) and cancer cells plays an important role in metastatic dissemination. Whether cancer stem cells can alter the metastatic properties of non-CSC cells; and whether exosomal crosstalk can mediate such interaction, have not been demonstrated in melanoma prior to this report. Results: The results revealed that exosomes secreted by highly metastatic melanoma CSCs (OL-SCs) promoted the invasiveness of the low metastatic melanoma cells (OL) and accelerated metastatic progression. miR-1268a was up-regulated in cells and exosomes of OL-SCs. Moreover, OL-SCs-derived exosomal miR-1268a, upon taking up by OL cells, promoted the metastatic colonization ability of OL cells in vitro and in vivo. In addition, the pro-metastatic activity of exosomal miR-1268a is achieved through inhibition of autophagy. Conclusion: Our study demonstrates that OL cells can acquire the “metastatic ability” from OL-SCs cells. OL-SCs cells achieves this goal by utilizing its exosomes to deliver functional miRNAs, such as miR-1268a, to the targeted OL cells which in turn augments metastatic colonization by inactivating the autophagy pathway in OL cells. |
| مصطلحات الفهرس: | Melanoma stem cells, Exosomes, miR-1268a, Metastasis, Autophagy |
| URL: | 10.1186/s40659-022-00397-z |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | text/html Sociedad de Biología de Chile English |
| أرقام أخرى: | CN@ oai:scielo:S0716-97602022000100222 1381533877 |
| المصدر المساهم: | CONICYT From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1381533877 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |