مورد إلكتروني
In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity
| العنوان: | In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity |
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| بيانات النشر: | Springer 2022 |
| تفاصيل مُضافة: | Universidade de Santiago de Compostela. Departamento de Anatomía, Produción Animal e Ciencias Clínicas Veterinarias Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica Universidade de Santiago de Compostela. Departamento de Fisioloxía Raposo García, Sandra Boente Juncal, Andrea Camiña García, María Mercedes Costas Sánchez, Celia Cao-Cancelas, Alejandro Louzao Ojeda, María Carmen Cifuentes Martínez, José Manuel Vale González, María del Carmen Botana López, Luis Miguel Rodriguez Vieytes, Mercedes |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Ciguatoxins are marine compounds that share a ladder-shaped polyether structure produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa, and include maitotoxins (MTX1 and MTX3), ciguatoxins (CTX3C) and analogues (gambierone), components of one of the most frequent human foodborne illness diseases known as ciguatera fish poisoning. This disease was previously found primarily in tropical and subtropical areas but nowadays, the dinoflagellates producers of ciguatoxins had spread to European coasts. One decade ago, the European Food Safety Authority has raised the need to complete the toxicological available data for the ciguatoxin group of compounds. Thus, in this work, the in vivo effects of ciguatoxin-related compounds have been investigated using internationally adopted guidelines for the testing of chemicals. Intraperitoneal acute toxicity was tested for maitotoxin 1 at doses between 200 and 3200 ng/kg and the acute oral toxicity of Pacific Ciguatoxin CTX3C at 330 and 1050 ng/kg and maitotoxin 1 at 800 ng/kg were also evaluated showing not effects on mice survival after a 96 h observation period. Therefore, for the following experiments the oral subchronic doses were between 172 and 1760 ng/kg for gambierone, 10 and 102 ng/kg for Pacific Ciguatoxin CTX3C, 550 and 1760 ng/kg for maitotoxin 3 and 800, 2560 and 5000 ng/kg for maitotoxin 1. The results presented here raise the need to reevaluate the in vivo activity of these agents. Although the intraperitoneal lethal dose of maitotoxin 1 is assumed to be 50 ng/kg, without chemical purity identifications and description of the bioassay procedures, in this work, an intraperitoneal lethal dose of 1107 ng/kg was obtained. Therefore, the data presented here highlight the need to use a common procedure and certified reference material to clearly establish the levels of these environmental contaminants in food |
| مصطلحات الفهرس: | Maitotoxin 1, Ciguatoxin, Gambierone, Maitotoxin 3 (MTX3) or 44-methylgambierone, Ciguatera fish poisoning, In vivo, Acute toxicity, Subchronic toxicity, journal article |
| URL: | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID 2020-11262RB-C21/ES info:eu-repo/grantAgreement/EC/H2020-EMERTOX/778069 |
| الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by/4.0 open access © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0 |
| ملاحظة: | English |
| أرقام أخرى: | ESUSC oai:minerva.usc.es:10347/29169 Archives of Toxicology 96, 2621–2638 (2022). https://doi.org/10.1007/s00204-022-03315-0 0340-5761 10.1007/s00204-022-03315-0 1432-0738 1400998533 |
| المصدر المساهم: | UNIVERSIDADE DE SANTIAGO DE COMPOSTELA From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1400998533 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |