مورد إلكتروني
Adrenomedullin Enhances Mouse Gustatory Nerve Responses to Sugars via T1R-Independent Sweet Taste Pathway
| العنوان: | Adrenomedullin Enhances Mouse Gustatory Nerve Responses to Sugars via T1R-Independent Sweet Taste Pathway |
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| بيانات النشر: | MDPI 2023-06-28 |
| تفاصيل مُضافة: | Iwata, Shusuke Yoshida, Ryusuke Takai, Shingo Sanematsu, Keisuke Shigemura, Noriatsu Ninomiya, Yuzo |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | On the tongue, the T1R-independent pathway (comprising glucose transporters, including sodium-glucose cotransporter (SGLT1) and the K-ATP channel) detects only sugars, whereas the T1R-dependent (T1R2/T1R3) pathway can broadly sense various sweeteners. Cephalic-phase insulin release, a rapid release of insulin induced by sensory signals in the head after food-related stimuli, reportedly depends on the T1R-independent pathway, and the competitive sweet taste modulators leptin and endocannabinoids may function on these two different sweet taste pathways independently, suggesting independent roles of two oral sugar-detecting pathways in food intake. Here, we examined the effect of adrenomedullin (ADM), a multifunctional regulatory peptide, on sugar sensing in mice since it affects the expression of SGLT1 in rat enterocytes. We found that ADM receptor components were expressed in T1R3-positive taste cells. Analyses of chorda tympani (CT) nerve responses revealed that ADM enhanced responses to sugars but not to artificial sweeteners and other tastants. Moreover, ADM increased the apical uptake of a fluorescent D-glucose derivative into taste cells and SGLT1 mRNA expression in taste buds. These results suggest that the T1R-independent sweet taste pathway in mouse taste cells is a peripheral target of ADM, and the specific enhancement of gustatory nerve responses to sugars by ADM may contribute to caloric sensing and food intake. |
| مصطلحات الفهرس: | taste, sweet taste, taste receptor family 1 members 2 and 3, sodium-glucose cotransporter 1, adrenomedullin, caloric sensing, Journal Article, VoR |
| URL: | 37447268 |
| الإتاحة: | Open access content. Open access content © 2023 by the authors. |
| ملاحظة: | English |
| أرقام أخرى: | JPNII oai:irdb.nii.ac.jp:01081:0005889133 2072-6643 Nutrients, 15(13), 2941- 1409767271 |
| المصدر المساهم: | NATIONAL INST OF INFO From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1409767271 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |