مورد إلكتروني
Chronic kidney disease increases the susceptibility to negative effects of low and high potassium intake
| العنوان: | Chronic kidney disease increases the susceptibility to negative effects of low and high potassium intake |
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| المؤلفون: | Gritter, M, Wei, KY, Wouda, RD, Musterd-Bhaggoe, UM, Dijkstra, KL, Kers, J, Ramakers, C, Vogt, L, de Borst, MH, Danser, AHJ, Hoorn, EJ, Rotmans, J |
| المصدر: | Gritter , M , Wei , KY , Wouda , RD , Musterd-Bhaggoe , UM , Dijkstra , KL , Kers , J , Ramakers , C , Vogt , L , de Borst , MH , Danser , AHJ , Hoorn , EJ & Rotmans , J 2024 , ' Chronic kidney disease increases the susceptibility to negative effects of low and high potassium intake ' , Nephrology Dialysis Transplantation , vol. 39 , no. 5 , gfad220 , pp. 795-807 . |
| بيانات النشر: | 2024-05-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background Dietary potassium (K+) has emerged as a modifiable factor for cardiovascular and kidney health in the general population, but its role in people with chronic kidney disease (CKD) is unclear. Here, we hypothesize that CKD increases the susceptibility to the negative effects of low and high K+ diets. Methods We compared the effects of low, normal and high KChloride (KCl) diets and a high KCitrate diet for 4 weeks in male rats with normal kidney function and in male rats with CKD using the 5/6th nephrectomy model (5/6Nx). Results Compared with rats with normal kidney function, 5/6Nx rats on the low KCl diet developed more severe extracellular and intracellular K+ depletion and more severe kidney injury, characterized by nephromegaly, infiltration of T cells and macrophages, decreased estimated glomerular filtration rate and increased albuminuria. The high KCl diet caused hyperkalemia, hyperaldosteronism, hyperchloremic metabolic acidosis and severe hypertension in 5/6Nx but not in sham rats. The high KCitrate diet caused hypochloremic metabolic alkalosis but attenuated hypertension despite higher abundance of the phosphorylated sodium chloride cotransporter (pNCC) and similar levels of plasma aldosterone and epithelial sodium channel abundance. All 5/6Nx groups had more collagen deposition than the sham groups and this effect was most pronounced in the high KCitrate group. Plasma aldosterone correlated strongly with kidney collagen deposition. Conclusions CKD increases the susceptibility to negative effects of low and high K+ diets in male rats, although the injury patterns are different. The low K+ diet caused inflammation, nephromegaly and kidney function decline, whereas the high K+ diet caused hypertension, hyperaldosteronism and kidney fibrosis. High KCitrate attenuated the hypertensive but not the pro-fibrotic effect of high KCl, which may be attributable to K+-induced aldosterone secretion. Our data suggest t |
| مصطلحات الفهرس: | article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | QGQ oai:pure.eur.nl:publications/3479056a-2da6-4c5f-b072-6abe61744e11 https://pure.eur.nl/en/publications/3479056a-2da6-4c5f-b072-6abe61744e11 https://doi.org/10.1093/ndt/gfad220 https://pure.eur.nl/ws/files/118048697/gfad220.pdf 1410089976 |
| المصدر المساهم: | ERASMUS UNIVERSITEIT ROTTERDAM From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1410089976 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |