مورد إلكتروني
Enantioselective synthesis of 3-hydroxy- and 3-amino-3-alkynyl-2-oxindoles by the dimethylzinc-mediated addition of terminal alkynes to isatins and isatin-derived ketimines
| العنوان: | Enantioselective synthesis of 3-hydroxy- and 3-amino-3-alkynyl-2-oxindoles by the dimethylzinc-mediated addition of terminal alkynes to isatins and isatin-derived ketimines |
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| بيانات النشر: | The Royal Society of Chemistry 2023 |
| تفاصيل مُضافة: | Prieto, Elena |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Producción Científica A common protocol for enantioselective alkynylation of isatins and isatin-derived ketimines using terminal alkynes and Me2Zn in the presence of a catalytic amount of a chiral perhydro-1,3-benzoxazine with moderate to excellent enantioselectivity under mild reaction conditions is described. The additions to ketimines present a novel approach to chiral amines being derivatives of oxindoles. The reaction is broad in scope with respect to aryl- and alkyl-substituted terminal alkynes and isatin derivatives. In isatins, the alkynylation occurs at the Si face of the carbonyl group, whereas in the ketimine derivatives it occurs at the Re face of the imine. Junta de Castilla y León, proyectos FEDER-VA115P17 y VA149G18 |
| مصطلحات الفهرس: | Catálisis enantioselectiva, compuestos organozíncicos, alquinilación, isatinas e iminas derivadas de isatinas, 2306.99 Química Orgánica-Síntesis enatioselectiva, info:eu-repo/semantics/article, info:eu-repo/semantics/acceptedVersion |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess The Royal Society of Chemistry |
| ملاحظة: | application/pdf Spanish |
| أرقام أخرى: | ESUDE oai:uvadoc.uva.es:10324/63063 https://doi.org/10.1039/d3ob01023f Organic and Biomolecular. Chemistry, 2023, vol.21, n 34, p 6940-69-48 1477-0520 https://uvadoc.uva.es/handle/10324/63063 6940 34 6948 Organic & Biomolecular Chemistry 21 1477-0539 1415715708 |
| المصدر المساهم: | UNIVERSIDAD DE VALLADOLID From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1415715708 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |