مورد إلكتروني
P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules
| العنوان: | P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules |
|---|---|
| بيانات النشر: | MDPI 2019 |
| تفاصيل مُضافة: | Universidad de Sevilla. Departamento de Química orgánica Willot, Sébastien Jean-Paul Tieves, Florian Girhard, Marco Urlacher, Vlada B. Hollmann, Frank Gonzalo Calvo, Gonzalo de |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | A set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus megaterium in H2O2-dependent oxidation reactions. These DFSMs enhance P450BM3 activity with hydrogen peroxide as an oxidant, converting these enzymes into formal peroxygenases. This system has been employed for the catalytic epoxidation of styrene and in the sulfoxidation of thioanisole. Various P450BM3 variants have been evaluated in terms of activity and selectivity of the peroxygenase reactions. |
| مصطلحات الفهرس: | Biocatalysis, Cytochrome P450, Dual functional small molecules, Epoxidations, Sulfoxidation, info:eu-repo/semantics/article |
| URL: | Catalysts, 9 (7), 567-1-567-9. CTQ2016-76908-C2-1,2-P ERC-648026 H2020-BBI-PPP-2015-2-1-720297 VICI-724.014.003 |
| الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| ملاحظة: | English |
| أرقام أخرى: | SUE oai:idus.us.es:11441/88633 Willot, S.J., Tieves, F., Girhard, M., Urlacher, V.B., Hollmann, F. y Gonzalo Calvo, G.d. (2019). P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules. Catalysts, 9 (7), 567-1-567-9. 2073-4344 10.3390/catal9070567 1416034728 |
| المصدر المساهم: | UNIV DE SEVILLA From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1416034728 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |