مورد إلكتروني
PIK3CA testing in hormone receptor-positive/HER2-negative metastatic breast cancer: real-world data from Italian molecular pathology laboratories
| العنوان: | PIK3CA testing in hormone receptor-positive/HER2-negative metastatic breast cancer: real-world data from Italian molecular pathology laboratories |
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| المؤلفون: | Pepe, F, Venetis, K, Cursano, G, Frascarelli, C, Pisapia, P, Vacirca, D, Scimone, C, Rappa, A, Russo, G, Mane, E, Pagni, F, Castellano, I, Troncone, G, De Angelis, C, Curigliano, G, Guerini-Rocco, E, Malapelle, U, Fusco, N |
| بيانات النشر: | Future Medicine country:GB 2024 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Introduction:PIK3CA gene mutations occur in approximately 40% of hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancers (MBCs), electing them to targeted therapy. Testing PIK3CA status is complex due to selection of biological specimen and testing method. Materials & methods: This work investigates real-life experience on PIK3CA testing in HR+/HER2- MBC. Clinical, technical and molecular data on PIK3CA testing were collected from two referral laboratories. Additionally, the results of a nationwide PIK3CA survey involving 116 institutions were assessed. Results: Overall, n = 35 MBCs were PIK3CA-mutated, with mutations mostly occurring in exons 9 (n = 19; 51.4%) and 20 (n = 15; 40.5%). The nationwide survey revealed significant variability across laboratories in terms of sampling methodology, technical assessment and clinical report signing healthcare figures for PIK3CA molecular testing in diagnostic routine practice. Conclusion: This study provides insights into the real-world routine of PIK3CA testing in HR+/HER2- MBC and highlights the need for standardization and networking in predictive pathology. |
| مصطلحات الفهرس: | breast cancer, molecular testing, PIK3CA, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/38440825 info:eu-repo/semantics/altIdentifier/wos/WOS:001179540200001 volume:25 issue:3 firstpage:161 lastpage:169 numberofpages:9 journal:PHARMACOGENOMICS |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | ELETTRONICO English |
| أرقام أخرى: | ITBAO oai:boa.unimib.it:10281/463620 10.2217/pgs-2023-0238 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85188761195 1427430873 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1427430873 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |