مورد إلكتروني
Acylation of glycerolipids in mycobacteria
| العنوان: | Acylation of glycerolipids in mycobacteria |
|---|---|
| المؤلفون: | National Institute of Allergy and Infectious Diseases (US), National Institutes of Health (US), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Kumar Angala, Shiva, Carreras-Gonzalez, Ana, Huc-Claustre, Emilie, Anso, Itxaso, Kaur, Devinder, Jones, Victoria, Palčeková, Zuzana, Belardinelli, Juan M., Sousa-d’Auria, Célia de, Shi, Libin, Slama, Nawel, Houssin, Christine, Quémard, Annaïk, McNeil, Michael, Guerin, Marcelo E., Jackson, Mary |
| بيانات النشر: | Nature Publishing Group 2023-10-23 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | We report on the existence of two phosphatidic acid biosynthetic pathways in mycobacteria, a classical one wherein the acylation of the sn-1 position of glycerol-3-phosphate (G3P) precedes that of sn-2 and another wherein acylations proceed in the reverse order. Two unique acyltransferases, PlsM and PlsB2, participate in both pathways and hold the key to the unusual positional distribution of acyl chains typifying mycobacterial glycerolipids wherein unsaturated substituents principally esterify position sn-1 and palmitoyl principally occupies position sn-2. While PlsM selectively transfers a palmitoyl chain to the sn-2 position of G3P and sn-1-lysophosphatidic acid (LPA), PlsB2 preferentially transfers a stearoyl or oleoyl chain to the sn-1 position of G3P and an oleyl chain to sn-2-LPA. PlsM is the first example of an sn-2 G3P acyltransferase outside the plant kingdom and PlsB2 the first example of a 2-acyl-G3P acyltransferase. Both enzymes are unique in their ability to catalyze acyl transfer to both G3P and LPA. |
| مصطلحات الفهرس: | Bacterial physiology, Phospholipids, artículo |
| URL: | Publisher's version The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1038/s41467-023-42478-x Sí info:eu-repo/grantAgreement/MINECO//BFU2016-77427-C2-2-R info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105649RB-I00/ES/BASES ESTRUCTURALES DE LA DIVERSIDAD DE GLICANOS info:eu-repo/grantAgreement/AEI//PID2022-138694OB-I00 |
| الإتاحة: | Open access content. Open access content https://creativecommons.org/licenses/by/4.0 openAccess |
| ملاحظة: | English |
| أرقام أخرى: | CTK oai:digital.csic.es:10261/343595 Nature Communications 14: 6694 (2023) 10.1038/s41467-023-42478-x 2041-1723 1431959099 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1431959099 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |