مورد إلكتروني
Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS):Focus on Long COVID
| العنوان: | Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS):Focus on Long COVID |
|---|---|
| المؤلفون: | Kell, Douglas B., Khan, Muhammed Asad, Kane, Binita, Lip, Gregory Y.H., Pretorius, Etheresia |
| المصدر: | Kell , D B , Khan , M A , Kane , B , Lip , G Y H & Pretorius , E 2024 , ' Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS) : Focus on Long COVID ' , Journal of Personalized Medicine , vol. 14 , no. 2 , 170 . |
| بيانات النشر: | 2024 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Postural orthostatic tachycardia syndrome (POTS) is a common accompaniment of a variety of chronic, inflammatory diseases, including long COVID, as are small, insoluble, ‘fibrinaloid’ microclots. We here develop the argument, with accompanying evidence, that fibrinaloid microclots, through their ability to block the flow of blood through microcapillaries and thus cause tissue hypoxia, are not simply correlated with but in fact, by preceding it, may be a chief intermediary cause of POTS, in which tachycardia is simply the body’s exaggerated ‘physiological’ response to hypoxia. Similar reasoning accounts for the symptoms bundled under the term ‘fatigue’. Amyloids are known to be membrane disruptors, and when their targets are nerve membranes, this can explain neurotoxicity and hence the autonomic nervous system dysfunction that contributes to POTS. Taken together as a system view, we indicate that fibrinaloid microclots can serve to link POTS and fatigue in long COVID in a manner that is at once both mechanistic and explanatory. This has clear implications for the treatment of such diseases. |
| مصطلحات الفهرس: | Fibrinaloid microclots, Long COVID, Postural orthostatic tachycardia syndrome (POTS), TeamClots, article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | EDN oai:pure.atira.dk:publications/fe33e535-ff96-4ad0-b0de-22a1e9d90ec0 1439389876 |
| المصدر المساهم: | TECHNICAL KNOWLEDGE CTR DENMARK From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1439389876 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |