مورد إلكتروني
The Ying and Yang of Hydrogen Sulfide as a Paracrine/Autocrine Agent in Neurodegeneration: Focus on Amyotrophic Lateral Sclerosis
| العنوان: | The Ying and Yang of Hydrogen Sulfide as a Paracrine/Autocrine Agent in Neurodegeneration: Focus on Amyotrophic Lateral Sclerosis |
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| المؤلفون: | Spalloni, A., de Stefano, S., Gimenez, J., Greco, Viviana, Mercuri, N. B., Chiurchiu, V., Longone, P., Greco V. (ORCID:0000-0003-4521-0020) |
| بيانات النشر: | MDPI 2023 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Ever since its presence was reported in the brain, the nature and role of hydrogen sulfide (H2S) in the Central Nervous System (CNS) have changed. Consequently, H2S has been elected as the third gas transmitter, along with carbon monoxide and nitric oxide, and a number of studies have focused on its neuromodulatory and protectant functions in physiological conditions. The research on H2S has highlighted its many facets in the periphery and in the CNS, and its role as a double-faced compound, switching from protective to toxic depending on its concentration. In this review, we will focus on the bell-shaped nature of H2S as an angiogenic factor and as a molecule released by glial cells (mainly astrocytes) and non-neuronal cells acting on the surrounding environment (paracrine) or on the releasing cells themselves (autocrine). Finally, we will discuss its role in Amyotrophic Lateral Sclerosis, a paradigm of a neurodegenerative disease. |
| مصطلحات الفهرس: | astrocytes, hydrogen sulfide, motor neuron, neurodegeneration, oligodendrocytes, Settore BIO/10 - BIOCHIMICA, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/37443723 info:eu-repo/semantics/altIdentifier/wos/WOS:001033259700001 volume:12 issue:13 firstpage:1 lastpage:17 numberofpages:17 issueyear:2023 journal:CELLS |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | English |
| أرقام أخرى: | SYC oai:publicatt.unicatt.it:10807/262254 10.3390/cells12131691 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85164720968 1439663996 |
| المصدر المساهم: | UNIV CATTOLICA DEL SACRO CUORE From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1439663996 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |