مورد إلكتروني
Surgical management and outcome of newly diagnosed glioblastoma without contrast enhancement ('low grade appearance') - a report of the RANO resect group
| العنوان: | Surgical management and outcome of newly diagnosed glioblastoma without contrast enhancement ('low grade appearance') - a report of the RANO resect group |
|---|---|
| المؤلفون: | Karschnia, Philipp; https://orcid.org/0000-0002-1254-5310, Dietrich, Jorg, Bruno, Francesco; https://orcid.org/0000-0001-8087-5293, Dono, Antonio; https://orcid.org/0000-0002-8041-8399, Juenger, Stephanie T, Teske, Nico, Young, Jacob S, Sciortino, Tommaso, Häni, Levin, van den Bent, Martin, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Vogelbaum, Michael A, Morshed, Ramin A, Haddad, Alexander F, Molinaro, Annette M; https://orcid.org/0000-0002-9854-7404, Tandon, Nitin; https://orcid.org/0000-0002-2752-2365, Beck, Juergen, Schnell, Oliver, Bello, Lorenzo, Hervey-Jumper, Shawn, Thon, Niklas, Grau, Stefan J, Esquenazi, Yoshua; https://orcid.org/0000-0002-9757-1453, Rudà, Roberta, Chang, Susan M, Berger, Mitchel S; https://orcid.org/0000-0003-1983-4892, Cahill, Daniel P; https://orcid.org/0000-0003-2552-6546, Tonn, Joerg-Christian; https://orcid.org/0009-0004-1756-423X |
| المصدر: | Karschnia, Philipp; Dietrich, Jorg; Bruno, Francesco; Dono, Antonio; Juenger, Stephanie T; Teske, Nico; Young, Jacob S; Sciortino, Tommaso; Häni, Levin; van den Bent, Martin; Weller, Michael; Vogelbaum, Michael A; Morshed, Ramin A; Haddad, Alexander F; Molinaro, Annette M; Tandon, Nitin; Beck, Juergen; Schnell, Oliver; Bello, Lorenzo; Hervey-Jumper, Shawn; Thon, Niklas; Grau, Stefan J; Esquenazi, Yoshua; Rudà, Roberta; Chang, Susan M; Berger, Mitchel S; Cahill, Daniel P; Tonn, Joerg-Christian (2024). Surgical management and outcome of newly diagnosed glioblastoma without contrast enhancement ('low grade appearance') - a report of the RANO resect group. Neuro-Oncology, 26(1):166-177. |
| بيانات النشر: | Oxford University Press 2024-01-05 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND: Resection of the contrast-enhancing (CE) tumor represents the standard of care in newly diagnosed glioblastoma. However, some tumors ultimately diagnosed as glioblastoma lack contrast enhancement and have a 'low grade appearance' on imaging (non-CE glioblastoma). We aimed to (I) volumetrically define the value of non-CE tumor resection in the absence of contrast enhancement, and to (II) delineate outcome differences between glioblastoma patients with and without contrast enhancement. METHODS: The RANO resect group retrospectively compiled a global, eight-center cohort of patients with newly diagnosed glioblastoma per WHO 2021 classification. The associations between post-operative tumor volumes and outcome were analyzed. Propensity score-matched analyses were constructed to compare glioblastomas with and without contrast enhancement. RESULTS: Among 1323 newly diagnosed IDH-wildtype glioblastomas, we identified 98 patients (7.4%) without contrast enhancement. In such patients, smaller post-operative tumor volumes were associated with more favourable outcome. There was an exponential increase in risk for death with larger residual non-CE tumor. Accordingly, extensive resection was associated with improved survival compared to lesion biopsy. These findings were retained on a multivariable analysis adjusting for demographic and clinical markers. Compared to CE glioblastoma, patients with non-CE glioblastoma had more favourable clinical profile and superior outcome as confirmed in propensity score analyses by matching the patients with non-CE glioblastoma to patients with CE glioblastoma using a large set of clinical variables. CONCLUSIONS: The absence of contrast enhancement characterizes a less aggressive clinical phenotype of IDH-wildtype glioblastomas. Maximal resection of non-CE tumors has prognostic implications and translates into favourable outcome. |
| مصطلحات الفهرس: | Clinic for Neurology, 610 Medicine & health, WHO 2021; contrast enhancement; extent of resection; glioblastoma; surgery, Journal Article, PeerReviewed, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | 10.1093/neuonc/noad160 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf info:doi/10.5167/uzh-239859 English English |
| أرقام أخرى: | CHUZH oai:www.zora.uzh.ch:239859 https://www.zora.uzh.ch/id/eprint/239859/1/noad160.pdf info:doi/10.5167/uzh-239859 info:doi/10.1093/neuonc/noad160 info:pmid/37665776 urn:issn:1522-8517 1443055253 |
| المصدر المساهم: | HAUPTBIBLIOTHEK UNIV OF ZURICH From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1443055253 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |