مورد إلكتروني
Where do we stand on fMRI in awake mice?
| العنوان: | Where do we stand on fMRI in awake mice? |
|---|---|
| المؤلفون: | Mandino, F., Vujic, S., Grandjean, J., Lake, E.M.R. |
| المصدر: | Cerebral Cortex, 34, 1, pp. bhad478 |
| بيانات النشر: | 2024 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Contains fulltext : 305231.pdf (Publisher’s version ) (Open Access) Imaging awake animals is quickly gaining traction in neuroscience as it offers a means to eliminate the confounding effects of anesthesia, difficulties of inter-species translation (when humans are typically imaged while awake), and the inability to investigate the full range of brain and behavioral states in unconscious animals. In this systematic review, we focus on the development of awake mouse blood oxygen level dependent functional magnetic resonance imaging (fMRI). Mice are widely used in research due to their fast-breeding cycle, genetic malleability, and low cost. Functional MRI yields whole-brain coverage and can be performed on both humans and animal models making it an ideal modality for comparing study findings across species. We provide an analysis of 30 articles (years 2011-2022) identified through a systematic literature search. Our conclusions include that head-posts are favorable, acclimation training for 10-14 d is likely ample under certain conditions, stress has been poorly characterized, and more standardization is needed to accelerate progress. For context, an overview of awake rat fMRI studies is also included. We make recommendations that will benefit a wide range of neuroscience applications. |
| مصطلحات الفهرس: | Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience, Cognitive Neuroscience - Radboud University Medical Center, Article / Letter to editor |
| URL: | |
| الإتاحة: | Open access content. Open access content |
| أرقام أخرى: | NLQGE oai:repository.ubn.ru.nl:2066/305231 10.1093/cercor/bhad478 1443486956 |
| المصدر المساهم: | RADBOUD UNIVERSITEIT NAJMEGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الأكسشن: | edsoai.on1443486956 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |