كتاب إلكتروني
Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers
| العنوان: | Chapter Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers |
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| المؤلفون: | Lange, F., Bale, G., Kaynezhad, P., Pollock, R.D., Stevenson, A., Tachtsidis, I. |
| بيانات النشر: | Springer Nature; Oxygen Transport to Tissue XLI, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | Book chapters Imported or submitted locally |
| Original Material: | d859fbd3-d884-4090-a0ec-baf821c9abfd ccf57905-ab3b-49f9-b482-fdf984cb3c17 6c6992af-b843-4f46-859c-f6e9998e40d5 |
| مصطلحات موضوعية: | NIRS, Broadband, Cytochrome-c-oxidase, Ischaemia, Human centrifuge, bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBG Medical equipment & techniques |
| الوصف: | We used a miniature broadband NIRS system to monitor concentration changes in brain oxygenation (oxy- and deoxy- haemoglobin [HbO2], [HHb]) and oxidised cytochrome-c-oxidase ([oxCCO]) during a high +Gz acceleration, induced by a human centrifuge, on two healthy experienced volunteers (2 male, 34 and 37 years). We performed a sequence of several +Gz exposures that were terminated at the onset of visual symptoms (loss of peripheral vision). Systemic parameters were recorded (i.e. heart rate, blood pressure and arterial saturation), and brain tissue blood volume changes ([HbT] = [HbO2] + [HHb]) and oxygen delivery ([HbDiff] = [HbO2] - [HHb]) were calculated. Volunteer 1 demonstrated a decrease in [HbT] of −3.49 ± 0.02 μMol and [HbDiff] of −3.23 ± 0.44 μMol, and an increase of [oxCCO] of 0.42 ± 0.01μMol. Volunteer 2 demonstrated a decrease in [HbDiff] of −4.37 ± 0.23 μMol, and no significant change in [HbT] (0.53 ± 0.06 μMol) and [oxCCO] (0.09 ± 0.06 μMol). The variability of the brain metabolic response was related to the level of ischaemia, suggesting that suppression of metabolism was due to lack of glucose substrate delivery rather than oxygen availability. |
| ملاحظة حول المحتويات: | 104580/Z/14/Z |
| نوع الوثيقة: | chapter |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-3-030-34459-7 3-030-34459-2 |
| DOI: | 10.1007/978-3-030-34461-0_43 |
| URL الوصول: | https://library.oapen.org/handle/20.500.12657/56699 |
| حقوق: | Attribution 4.0 International URL: https://creativecommons.org/licenses/by/4.0/ |
| ملاحظات: | Wellcome Trust Wellcome |
| رقم الأكسشن: | edsoap.20.500.12657.56699 |
| قاعدة البيانات: | OAPEN Library |
| ردمك: | 9783030344597 3030344592 |
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| DOI: | 10.1007/978-3-030-34461-0_43 |