دورية أكاديمية
Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning
| العنوان: | Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning |
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| المؤلفون: | Baron, Frédéric, Maris, M. B., Sandmaier, B. M., Storer, B. E., Sorror, M., Diaconescu, R., Woolfrey, A. E., Chauncey, T. R., Flowers, M. E. D., Mielcarck, M., Maloney, D. G., Storb, R. |
| المصدر: | Journal of Clinical Oncology, 23 (9), 1993-2003 (2005-03-20) |
| بيانات النشر: | Amer Soc Clinical Oncology, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Human health sciences, Hematology, Oncology, Sciences de la santé humaine, Hématologie, Oncologie |
| الوصف: | Purpose We have used a nonmyelorablative conditioning regimen consisting of total-body irradiation (2 Gy) with or without fludarabine (30 mg/m(2)/d for 3 days) for related and unrelated hematopoietic cell transplantation (HCT) in patients with hematologic malignancies who were not candidates for conventional HCT because of age, medical comorbidities, or preceding high-dose HCT. This approach relied on graft-versus-tumor (GVT) effects for control of malignancy. Patients and Methods We analyzed GVT effects in 322 patients given grafts from HILA-matched related (n = 192) or unrelated donors (n = 130). Results Of the 221 patients with measurable disease at HCT, 126 (57%) achieved complete (n = 98) or partial (n = 28) remissions. In multivariate analysis, there was a higher probability trend of achieving complete remissions in patients with chronic extensive graft-versus-host disease (GVHD, P = .07). One hundred eight patients (34%) relapsed or progressed. In multivariate analysis, achievement of full donor chimerism was associated with a decreased risk of relapse or progression (P = .002). Grade 2 to 4 acute GVHD had no significant impact on the risk of relapse or progression but was associated with increased risk of nonrelapse mortality and decreased probability of progression-free survival (PFS). Conversely, extensive chronic GVHD was associated with decreased risk of relapse or progression (P = .006) and increased probability of PFS (P = .003). Conclusion New approaches aimed at reducing the incidence of grade 2 to 4 acute GVHD might improve survival after allogeneic HCT after nonmyeloablative conditioning. (c) 2005 by American Society of Clinical Oncology. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:0732-183X; urn:issn:1527-7755 |
| DOI: | 10.1200/JCO.2005.08.136 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/102049 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.102049 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1200/JCO.2005.08.136 |
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