دورية أكاديمية
Rapid regulation of pain by estrogens synthesized in spinal dorsal horn neurons
| العنوان: | Rapid regulation of pain by estrogens synthesized in spinal dorsal horn neurons |
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| المؤلفون: | Evrard, H. C., Balthazart, Jacques |
| المصدر: | Journal of Neuroscience, 24 (33), 7225-7229 (2004-08-18) |
| بيانات النشر: | Soc Neuroscience, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | aromatase inhibitor, estrogens, rapid effects, nongenomic effects, membrane estrogen receptor, bird, Social & behavioral sciences, psychology, Neurosciences & behavior, Sciences sociales & comportementales, psychologie, Neurosciences & comportement |
| الوصف: | In addition to exerting genomic actions via nuclear receptors within hours to days, estrogens also regulate neuronal activity much faster (within seconds) by activating neuronal membrane receptors coupled to intracellular second-messenger pathways. To date, the origin of estrogens inducing rapid effects in the brain remains unclear, although it is often ascribed to the gonads. We report here that an acute blockade of the endogenous synthesis of estrogens in the quail spinal dorsal horn markedly reduced, within 1 min, the behavioral responsiveness to a thermal painful stimulus. Similar rapid effects in the opposite direction were induced by estradiol. This finding identifies a new paracrine and nongenomic mechanism for the regulation of pain by estrogens. Such regulation was assumed previously to result only from slow genomic actions of estrogens arising from the ovaries. Also, quite importantly, this finding suggests that the numerous rapid nongenomic effects of estrogens in the CNS could depend on their immediate local production by the enzyme aromatase, independently from the gonads. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:0270-6474; urn:issn:1529-2401 |
| DOI: | 10.1523/JNEUROSCI.1638-04.2004 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/11632 |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess |
| رقم الأكسشن: | edsorb.11632 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1523/JNEUROSCI.1638-04.2004 |
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