دورية أكاديمية
Modeling serum level of s100beta and bispectral index to predict outcome after cardiac arrest.
| العنوان: | Modeling serum level of s100beta and bispectral index to predict outcome after cardiac arrest. |
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| المؤلفون: | Stammet, Pascal, Wagner, Daniel R., Gilson, Georges, Devaux, Yvan |
| المصدر: | Journal of the American College of Cardiology, 62 (9), 851-8 (2013) |
| بيانات النشر: | Elsevier, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Aged, Aged, 80 and over, Biomarkers/blood, Brain/physiopathology, Consciousness Monitors, Female, Follow-Up Studies, Heart Arrest/blood/mortality/therapy, Humans, Male, Middle Aged, Nerve Growth Factors/blood, Phosphopyruvate Hydratase/blood, Predictive Value of Tests, Prognosis, Prospective Studies, Resuscitation, Risk Factors, S100 Calcium Binding Protein beta Subunit, S100 Proteins/blood, Sensitivity and Specificity, BIS, CA, CPC, EEG, ICU, IDI, NSE, ROSC, S100beta, SAPS, biomarkers, bispectral index, brain injury, cardiac arrest, cerebral performance category, electroencephalogram, electroencephalography, integrated discrimination improvement, intensive care unit, neuron-enriched S100 beta, neuron-specific enolase, return of spontaneous circulation, simplified acute physiology score, survival, Human health sciences, Anesthesia & intensive care, Sciences de la santé humaine, Anesthésie & soins intensifs |
| الوصف: | OBJECTIVES: This study was designed to evaluate multimodal prognostication in patients after cardiac arrest (CA). BACKGROUND: Accurate methods to predict outcome after CA are lacking. METHODS: Seventy-five patients with CA treated with therapeutic hypothermia after cardiac resuscitation were enrolled in this prospective observational study. Serum levels of neuron-specific enolase (NSE) and neuron-enriched S100 beta (S100beta) were measured 48 h after CA. Bispectral index (BIS) was continuously monitored during the first 48 h after CA. The primary endpoint was neurological outcome, as defined by the cerebral performance category (CPC) at 6-month follow-up: scores 1 or 2 indicated good outcome, and scores 3 to 5, poor outcome. The secondary endpoint was survival. RESULTS: A total of 46 (61%) patients survived at 6 months and 41 (55%) patients had CPC 1 or 2. Levels of NSE and S100beta were higher in patients with poor outcomes compared with patients with good outcomes (4-fold and 10-fold, respectively; p < 0.001). BIS was lower in patients with poor outcomes (10-fold; p < 0.001). NSE, S100beta, or BIS alone predicted neurological outcome, with areas under the receiver-operating characteristic curve (AUC) above 0.80. Combined determination of S100beta and BIS had an incremental predictive value (AUC: 0.95). S100beta improved discriminations based on BIS (p = 0.0008), and BIS improved discriminations based on S100beta (p < 10(-5)). Patients with S100beta level above 0.03 mug/l and BIS below 5.5 had a 3.6-fold higher risk of poor neurological outcome (p < 0.0001). S100beta and BIS predicted 6-month mortality (log-rank statistic: 50.41; p < 0.001). CONCLUSIONS: Combined determination of serum level of S100beta and BIS monitoring accurately predicts outcome after CA. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:0735-1097; urn:issn:1558-3597 |
| DOI: | 10.1016/j.jacc.2013.04.039 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/194907 |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess |
| رقم الأكسشن: | edsorb.194907 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1016/j.jacc.2013.04.039 |
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