دورية أكاديمية
Accumulation of IL-17+ Vgamma6+ gamma-delta T cells in pregnant mice is not associated with spontaneous abortion
| العنوان: | Accumulation of IL-17+ Vgamma6+ gamma-delta T cells in pregnant mice is not associated with spontaneous abortion |
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| المؤلفون: | Polese, Barbara, Gridelet, Virginie, Perrier d'Hauterive, Sophie, Charlet-Renard, Jeanne de Chantal, Munaut, Carine, Martens, Henri, Vermijlen, David, King, Irah L., Jacobs, Nathalie, Geenen, Vincent |
| المساهمون: | GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège |
| المصدر: | Clinical and Translational Immunology, 7, e1008 (2018-01-29) |
| بيانات النشر: | John Wiley & Sons, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Reproductive immunology, Gamma delta T cells, Interleukin 17, Pregnancy, Abortion, Human health sciences, Immunology & infectious disease, Reproductive medicine (gynecology, andrology, obstetrics), Sciences de la santé humaine, Immunologie & maladie infectieuse, Médecine de la reproduction (Gynécologie, andrologie, obstétrique) |
| الوصف: | Introduction. Pregnancy is an immune paradox. While the immune system is required for embryo implantation, placental development and progression of gestation, excessive inflammation is associated with pregnancy failure. Similarly, the cytokine IL-17A plays an important role in defence against extracellular pathogens, but its dysregulation can lead to pathogenic inflammation and tissue damage. Although expression of IL-17 has been reported during pregnancy, the cellular source of this cytokine and its relevance to gestation are not clear. Objectives. Here we define the kinetics and cellular source of IL-17A in the uterus during healthy and abortion-prone murine pregnancy. Methods. The CBA/J x DBA/2J abortion-prone mating was used and compared to CBA/J x BALB/c control mating. Results. We demonstrate that, irrespective of gestational health, the number of IL-17-producing cells peaks during midterm pregnancy and is largely derived from the gd T-cell lineage. We identify cd T, Th17, CD8 T and NKT cells as the cellular source of IL-17A in pregnant mice. Furthermore, we positively identify the Vc6+ subset of uterine gd T cells as the main producer of IL-17A during both healthy pregnancy and abortive pregnancy. Conclusions. To conclude, the accumulation of uterine IL-17+ innate-like T cells appears not to adversely impact the developing foetus. Collectively, our results show that IL-17+ gd T cells are present in the uterus throughout the course of normal gestation and therefore may play an important role in healthy pregnancy.Keywords: abortion, gamma delta T cells, interleukin-17, pregnancy. Implantation and Tolerance of the Embryo |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | http://www.wileyonlinelibrary.com/journal/cti; urn:issn:2050-0068 |
| DOI: | 10.1002/cti2.1008 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/220920 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.220920 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1002/cti2.1008 |
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