Somatotopic principle of perineural implantation of stem cells in patients with brain injuries. Journal of Neurology and Stroke, 8(5), 259-261., United StatesMedCrave Group. (2018).
Background: Neuro destructive processes of any etiology are related to problematic andsocially important diseases due to ineffective therapeutic strategy and need to search fornew successful ways of treatment and rehabilitation of patient with cerebral infarctionsand brain attacksAims: Authors plant overify hypothesis on viability of additional use of perineuralimplantation of autologous mesenchymal stem cells (MSC) in order to optimize standardtherapy of patients with brain attacks. Such combined technology is aim datextraactivation of brain plasticity mechanisms during development of neuro destructiveprocesses.Methods: The technique of MSC perineural migration to injured brain regions wasexperimentally verifed on rats (n=40) paying attention to somatotopic organization ofcranial nerves.This technique was clinically tested in pilot project. Phenotyping of autologous MSC fromadipose tissue (AT) was performed in 23 patients with brain attacks. These 23 patientsreceived standard treatment as per international guidelines together with three perineuralimplantations of autologous MSC from AT with 5-9days intervals. The other group ofpatients (n=7) received only standard therapy as per international guidelines.Results: Additional use of cell therapy resulted in more rapid and effective recovery ofdisordered neurological functions in all cases compared to those who received standardtherapy. The phenomenon of abrupt recovery of neurological functions was establishedduring frst 24hours after each injection of autologous MSC. Cumulative recovery offunctions progressed after each implantation.Discussion and conclusion: Experimentally developed technique of perineural implantationof autologous MSC was successfully verifed in clinical conditions in accordance withcertifed cell therapy guideline (The Ministry of Health of the Republic of Belarus) incombination with standard treatment of patients with cerebral infarctions. Cell therapywith autologous MSC from AT by means of perineural delivery to injured brain regions isthe basis for activation of reparative potential of nerve tissue and progressive recovery ofneurological functions in patients with cerebral infarctions.
