دورية أكاديمية
Rewiring of Lipid Metabolism and Storage in Ovarian Cancer Cells after Anti-VEGF Therapy
| العنوان: | Rewiring of Lipid Metabolism and Storage in Ovarian Cancer Cells after Anti-VEGF Therapy |
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| المؤلفون: | Curtarello, Matteo, Tognon, Martina, Venturoli, Carolina, Silic-Benussi, Micol, Grassi, Angela, Verza, Martina, Minuzzo, Sonia, Pinazza, Marica, Brillo, Valentina, Tosi, Giovanni, Ferrazza, Ruggero, Guella, Graziano, Iorio, Egidio, Godfroid, Adrien, Sounni, Nor Eddine, Amadori, Alberto, Stefano |
| المصدر: | Cells (2019) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute (MDPI), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Angiogenèse, Resistance, Métabolisme, Human health sciences, Oncology, Sciences de la santé humaine, Oncologie |
| الوصف: | Anti-angiogenic therapy triggers metabolic alterations in experimental and humantumors, the best characterized being exacerbated glycolysis and lactate production. By usingboth Liquid Chromatography-Mass Spectrometry (LC-MS) and Nuclear Magnetic Resonance (NMR)analysis, we found that treatment of ovarian cancer xenografts with the anti-Vascular EndothelialGrowth Factor (VEGF) neutralizing antibody bevacizumab caused marked alterations of the tumorlipidomic profile, including increased levels of triacylglycerols and reduced saturation of lipidchains. Moreover, transcriptome analysis uncovered up-regulation of pathways involved in lipidmetabolism. These alterations were accompanied by increased accumulation of lipid dropletsin tumors. This phenomenon was reproduced under hypoxic conditions in vitro, where it mainlydepended from uptake of exogenous lipids and was counteracted by treatment with the Liver XReceptor (LXR)-agonist GW3965, which inhibited cancer cell viability selectively under reduced serumconditions. This multi-level analysis indicates alterations of lipid metabolism following anti-VEGFtherapy in ovarian cancer xenografts and suggests that LXR-agonists might empower anti-tumore ects of bevacizumab. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:2073-4409 |
| DOI: | 10.3390/cells8121601 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/242379 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.242379 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.3390/cells8121601 |
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