دورية أكاديمية
Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent
| العنوان: | Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent |
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| المؤلفون: | Suy, K., Morias, K., Cammu, G., Hans, Pol, van Duijnhoven, W. G. F., Heeringa, M., Demeyer, I. |
| المصدر: | Anesthesiology, 106 (2), 283-288 (2007-02) |
| بيانات النشر: | Lippincott Williams & Wilkins, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Human health sciences, Anesthesia & intensive care, Sciences de la santé humaine, Anesthésie & soins intensifs |
| الوصف: | Background: Sugammadex rapidly reverses rocuronium-induced neuromuscular block. This study explored the dose-response relation of sugammadex given as a reversal agent at reappearance of the second muscle twitch after rocuronium and vecuronium-induced block. A secondary objective was to investigate the safety of single doses of sugammadex. Methods: in this two-center, phase II, dose-finding study, 80 patients (age >= 18 yr, American Society of Anesthesiologists physical status I or II, surgery >= 60 min requiring muscle relaxation for intubation) were randomly assigned to receive rocuronium (0.60 mg/kg) or vecuronium (0.10 mg/kg). Sugammadex or placebo was administered at reappearance of the second muscle twitch. The primary efficacy endpoint was time from starting sugammadex administration until recovery of the train-of-four ratio to 0.9. Results: Compared with placebo, sugammadex produced dose-dependent decreases in mean time to recovery for all train-of-four ratios in the rocuronium and vecuronium groups. The mean time for recovery of the train-of-four ratio to 0.9 in the rocuronium group was 31.8 min after placebo compared with 3.7 and 1.1 min after 0.5 and 4.0 mg/kg sugammadex, respectively. The mean time for recovery of the train-of-four ratio to 0.9 in the vecuronium group was 48.8 min after placebo, compared with 2.5 and 1.4 min after 1.0 and 8.0 mg/kg sugammadex, respectively. Sugammadex was well tolerated. Conclusion: Sugammadex rapidly reversed rocuronium- or vecuronium-induced neuromuscular block at reappearance of the second muscle twitch and was well tolerated. A dose-response relation was observed with sugammadex for reversal of both rocuronium- and vecuronium-induced neuromuscular block. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:0003-3022; urn:issn:1528-1175 |
| DOI: | 10.1097/00000542-200702000-00016 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/258455 |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess |
| رقم الأكسشن: | edsorb.258455 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1097/00000542-200702000-00016 |
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