دورية أكاديمية
On the pathophysiology and treatment of akinetic mutism
| العنوان: | On the pathophysiology and treatment of akinetic mutism |
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| المؤلفون: | Arnts, H., van Erp, Willemijn, Lavrijsen, J. C. M., van Gaal, S., Groenewegen, H. J., van den Munckhof, P. |
| المصدر: | Neuroscience and Biobehavioral Reviews, 112, 270-278 (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Akinetic mutism, Behavior, Disorders of diminished motivation, Frontal-subcortical neurocircuitry, Review, Human health sciences, Neurology, Sciences de la santé humaine, Neurologie |
| الوصف: | Akinetic mutism (AM) is a rare neurological disorder characterized by the presence of an intact level of consciousness and sensorimotor capacity, but with a simultaneous decrease in goal-directed behavior and emotions. Patients are in a wakeful state of profound apathy, seemingly indifferent to pain, thirst, or hunger. It represents the far end within the spectrum of disorders of diminished motivation. In recent years, more has become known about the functional roles of neurocircuits and neurotransmitters associated with human motivational behavior. More specific, there is an increasing body of behavioral evidence that links specific damage of functional frontal-subcortical organization to the occurrence of distinct neurological deficits. In this review, we combine evidence from lesion studies and neurophysiological evidence in animals, imaging studies in humans, and clinical investigations in patients with AM to form an integrative theory of its pathophysiology. Moreover, the specific pharmacological interventions that have been used to treat AM and their rationales are reviewed, providing a comprehensive overview for use in clinical practice. © 2020 The Authors |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:0149-7634; urn:issn:1873-7528 |
| DOI: | 10.1016/j.neubiorev.2020.02.006 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/266552 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.266552 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1016/j.neubiorev.2020.02.006 |
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