دورية أكاديمية
The Post-Acute Phase of SARS-CoV-2 Infection in Two Macaque Species Is Associated with Signs of Ongoing Virus Replication and Pathology in Pulmonary and Extrapulmonary Tissues.
| العنوان: | The Post-Acute Phase of SARS-CoV-2 Infection in Two Macaque Species Is Associated with Signs of Ongoing Virus Replication and Pathology in Pulmonary and Extrapulmonary Tissues. |
|---|---|
| المؤلفون: | Böszörményi, Kinga P, Stammes, Marieke A, Fagrouch, Zahra C, Kiemenyi-Kayere, Gwendoline, Niphuis, Henk, Mortier, Daniella, van Driel, Nikki, Nieuwenhuis, Ivonne, Vervenne, Richard A W, Haaksma, Tom, Ouwerling, Boudewijn, Adema, Deborah, Acar, Roja Fidel, Zuiderwijk-Sick, Ella, Meijer, Lisette, Mooij, Petra, Remarque, Ed J, Oostermeijer, Herman, Koopman, Gerrit, Hoste, Alexis, Sastre, Patricia, Haagmans, Bart L, Bontrop, Ronald E, Langermans, Jan A M, Bogers, Willy M, Kondova, Ivanela, Verschoor, Ernst J, Verstrepen, Babs E |
| المصدر: | Viruses, 13 (8), 1673 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | COVID-19, NHPs, SARS-CoV-2, animal models, non-human primates, Antibodies, Viral, Cytokines, RNA, Messenger, RNA, Viral, Animals, Antibodies, Viral/blood, COVID-19/immunology, COVID-19/pathology, COVID-19/virology, Cytokines/blood, Disease Models, Animal, Humans, Lung/pathology, Lung/virology, Lymph Nodes/pathology, Lymph Nodes/physiopathology, Macaca fascicularis, Macaca mulatta, RNA, Messenger/analysis, RNA, Viral/analysis, Respiratory System/pathology, Respiratory System/virology, SARS-CoV-2/immunology, SARS-CoV-2/physiology, Virus Replication, Lung, Lymph Nodes, Respiratory System, Infectious Diseases, Virology, Life sciences, Veterinary medicine & animal health, Sciences du vivant, Médecine vétérinaire & santé animale |
| الوصف: | The post-acute phase of SARS-CoV-2 infection was investigated in rhesus (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis). During the acute phase of infection, SARS-CoV-2 was shed via the nose and throat, and viral RNA was occasionally detected in feces. This phase coincided with a transient change in systemic immune activation. Even after the alleged resolution of the infection, computed tomography (CT) and positron emission tomography (PET)-CT revealed pulmonary lesions and activated tracheobronchial lymph nodes in all animals. Post-mortem histological examination of the lung tissue revealed mostly marginal or resolving minimal lesions that were indicative of SARS-CoV-2 infection. Evidence for SARS-CoV-2-induced histopathology was also found in extrapulmonary tissue samples, such as conjunctiva, cervical, and mesenteric lymph nodes. However, 5-6 weeks after SARS-CoV-2 exposure, upon necropsy, viral RNA was still detectable in a wide range of tissue samples in 50% of the macaques and included amongst others the heart, the respiratory tract and surrounding lymph nodes, salivary gland, and conjunctiva. Subgenomic messenger RNA was detected in the lungs and tracheobronchial lymph nodes, indicative of ongoing virus replication during the post-acute phase. These results could be relevant for understanding the long-term consequences of COVID-19 in humans. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | info:eu-repo/grantAgreement/EC/H2020/721367; https://www.mdpi.com/1999-4915/13/8/1673/pdf; urn:issn:1999-4915 |
| DOI: | 10.3390/v13081673 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/299118 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.299118 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.3390/v13081673 |
|---|