دورية أكاديمية
Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality.
| العنوان: | Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality. |
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| المؤلفون: | Brunet-Ratnasingham, Elsa, Anand, Sai Priya, Gantner, Pierre, Dyachenko, Alina, Moquin-Beaudry, Gaël, Brassard, Nathalie, Beaudoin-Bussières, Guillaume, Pagliuzza, Amélie, Gasser, Romain, Benlarbi, Mehdi, Point, Floriane, Prévost, Jérémie, Laumaea, Annemarie, Niessl, Julia, Nayrac, Manon, Sannier, Gérémy, Orban, Catherine, Messier-Peet, Marc, Butler-Laporte, Guillaume, Morrison, David R, Zhou, Sirui, Nakanishi, Tomoko, Boutin, Marianne, Descôteaux-Dinelle, Jade, Gendron-Lepage, Gabrielle, Goyette, Guillaume, Bourassa, Catherine, Medjahed, Halima, Laurent, Laetitia, Rébillard, Rose-Marie, Richard, Jonathan, Dubé, Mathieu, Fromentin, Rémi, Arbour, Nathalie, Prat, Alexandre, Larochelle, Catherine, Durand, Madeleine, Richards, J Brent, Chassé, Michaël, Tétreault, Martine, Chomont, Nicolas, Finzi, Andrés, Kaufmann, Daniel E |
| المصدر: | Science Advances, 7 (48), eabj5629 (2021-11-26) |
| بيانات النشر: | American Association for the Advancement of Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Antibody-dependent cellular cytotoxicities, Cytokines, Domain specific, Immunoglobulin G, Mechanical ventilation, Receptor-binding domains, Severe acute respiratory syndrome coronavirus, Three-variable models, Tissue injury, Viral RNA, Multidisciplinary, Human health sciences, Immunology & infectious disease, Sciences de la santé humaine, Immunologie & maladie infectieuse |
| الوصف: | Despite advances in COVID-19 management, identifying patients evolving toward death remains challenging. To identify early predictors of mortality within 60 days of symptom onset (DSO), we performed immunovirological assessments on plasma from 279 individuals. On samples collected at DSO11 in a discovery cohort, high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA (vRNA), low receptor binding domain–specific immunoglobulin G and antibody-dependent cellular cytotoxicity, and elevated cytokines and tissue injury markers were strongly associated with mortality, including in patients on mechanical ventilation. A three-variable model of vRNA, with predefined adjustment by age and sex, robustly identified patients with fatal outcome (adjusted hazard ratio for log-transformed vRNA = 3.5). This model remained robust in independent validation and confirmation cohorts. Since plasma vRNA’s predictive accuracy was maintained at earlier time points, its quantitation can help us understand disease heterogeneity and identify patients who may benefit from new therapies. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | urn:issn:2375-2548 |
| DOI: | 10.1126/sciadv.abj5629 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/303154 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.303154 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1126/sciadv.abj5629 |
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