كتاب
Cortical Neuron Migration in Health and Disease
| العنوان: | Cortical Neuron Migration in Health and Disease |
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| المؤلفون: | Javier Torrent, Míriam, Nguyen, Laurent |
| المصدر: | urn:isbn:978-1-119-81982-0 urn:isbn:978-1-119-86080-8 Neocortical Neurogenesis in Development and Evolution (2023) |
| بيانات النشر: | wiley, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | cellular crosstalk, cortical morphogenesis, interneurons, migration disorders, neuronal migration, projection neurons, Neuroscience (all), Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire |
| الوصف: | editorial reviewed The cerebral cortex is an evolutionary advanced brain structure whose spatiotemporal patterning underlies the production of specific cell types that form neuronal networks essential for the emergence of higher cognitive functions. Cell migration is key to orchestrate the formation of the cortex as most of its cells are generated during embryogenesis by progenitors that reside at a distance. The cerebral cortex contains two major classes of neurons that are born in the germinal part of the cortical wall for the excitatory projection neurons (PNs) and in the ganglionic eminences and preoptic area for cortical interneurons (cINs). While PNs migrate perpendicularly to the ventricular surface along the fibers of radial glia cells (radial migration), cINs navigate within multiple tangential routes (tangential migration) that are remodeled as corticogenesis proceeds. Impairment in cell migration often underlies cortical malformations. Therefore, better understanding the events that control this process is key to shed light on the cellular and molecular drivers of these diseases. This chapter summarizes some of the key mechanisms that regulate neuronal migration and neurogenesis during cerebral cortex formation and discusses how their impairment leads to brain disorders. |
| نوع الوثيقة: | book part http://purl.org/coar/resource_type/c_3248 bookPart editorial reviewed |
| اللغة: | English |
| Relation: | https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781119860914.ch17 |
| DOI: | 10.1002/9781119860914.ch17 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/316547 |
| رقم الأكسشن: | edsorb.316547 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1002/9781119860914.ch17 |
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