دورية أكاديمية
Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects.
| العنوان: | Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects. |
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| المؤلفون: | Hansenne, Michel, Pinto, Emmanuel, Scantamburlo, Gabrielle, Couvreur, Anne, Reggers, Jean, Fuchs, Sonia, Pitchot, William, Ansseau, Marc |
| المساهمون: | Centre de Neurosciences Comportementale et Cognitive |
| المصدر: | Human Psychopharmacology, 18 (3), 201-5 (2003) |
| بيانات النشر: | John Wiley & Sons, Inc, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Acoustic Stimulation/methods, Adult, Apomorphine/diagnostic use, Brain/physiology, Clonidine/diagnostic use, Contingent Negative Variation/physiology, Dopamine/metabolism, Evoked Potentials, Auditory/physiology, Female, Human Growth Hormone/blood, Humans, Male, Norepinephrine/metabolism, Social & behavioral sciences, psychology, Neurosciences & behavior, Sciences sociales & comportementales, psychologie, Neurosciences & comportement |
| الوصف: | The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings suggest that the scalp-recorded MMN reflects activity from multiple neuronal ensembles within or in the immediate vicinity of the primary auditory cortex and with possible contribution from the frontal cortex. However, few data are available concerning the influence of neurotransmitter systems on the MMN. In this study, the relationship between both noradrenergic and dopaminergic systems and the MMN were investigated in 34 healthy volunteers. Noradrenergic and dopaminergic activities were assessed with the apomorphine and clonidine challenge tests. The results showed no significant relationship between either growth hormone (GH) responses to apomorphine or clonidine and the MMN amplitude or latency. Therefore, this study does not demonstrate the implication of dopaminergic and noradrenergic activities as assessed by GH response to apomorphine and clonidine for the generation and/or the modulation of the MMN. However, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the MMN. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:0885-6222; urn:issn:1099-1077 |
| DOI: | 10.1002/hup.468 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/5221 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.5221 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1002/hup.468 |
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