دورية أكاديمية
Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly.
| العنوان: | Tumor ZAC1 expression is associated with the response to somatostatin analog therapy in patients with acromegaly. |
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| المؤلفون: | Theodoropoulou, Marily, Tichomirowa, Maria A, Sievers, Caroline, Yassouridis, Alexander, Arzberger, Thomas, Hougrand, Olivier, Deprez, Manuel, Daly, Adrian, Petrossians, Patrick, Pagotto, Uberto, Beckers, Albert, Stalla, Gunter K |
| المصدر: | International Journal of Cancer, 125 (9), 2122-6 (2009-11) |
| بيانات النشر: | Wiley Liss, Inc., 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Acromegaly/drug therapy, Adolescent, Adult, Aged, Cell Cycle Proteins/analysis, Cohort Studies, Female, Human Growth Hormone/blood, Humans, Insulin-Like Growth Factor I/analysis, Male, Middle Aged, Octreotide/therapeutic use, Peptides, Cyclic/therapeutic use, Pituitary Neoplasms/chemistry/drug therapy, Retrospective Studies, Somatostatin/analogs & derivatives/therapeutic use, Transcription Factors/analysis, Tumor Suppressor Proteins/analysis, Human health sciences, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition |
| الوصف: | Somatostatin analogs (SSA) with their potent antisecretory and antiproliferative effects are the main medical treatment option for patients with neuroendocrine tumors, such as gastroenteropancreatic and acromegaly-associated growth hormone secreting pituitary tumors. Although a good portion of acromegalic patients gets normalized after SSA treatment, strict hormonal control is not achieved in a sizeable proportion of these patients. The reasons for this incomplete response to SSA treatment are unclear. We have found that the tumor suppressor ZAC1 (LOT1/PLAGL1) is essential for the antiproliferative effect of SSA in pituitary tumor cells. The aim of the present retrospective cohort study was to determine whether ZAC1 immunoreactivity in archival somatotrophinoma tissue derived from 45 patients with acromegaly routinely pretreated with SSA before surgery, was associated with response to SSA (normalization of GH, IGF-I and presence of tumor shrinkage). All tumors displayed ZAC1 immunoreactivity [weak (+; n = 15), moderate (++; n = 16) and strong (+++; n = 14)]. A significant positive correlation was found between strong ZAC1 immunoreactivity and IGF-I normalization and presence of tumor shrinkage after SSA treatment, which was not affected by age at diagnosis, gender or duration of SSA treatment. These in vivo data combined with the antiproliferative properties of ZAC1/Zac1 provide evidence of a mechanistic role for this transcription factor on SSA induced tumor shrinkage and hormone normalization. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article peer reviewed |
| اللغة: | English |
| Relation: | urn:issn:0020-7136; urn:issn:1097-0215 |
| DOI: | 10.1002/ijc.24602 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/59309 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.59309 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1002/ijc.24602 |
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