دورية أكاديمية
Effect of membrane permeability on survival of hemodialysis patients
| العنوان: | Effect of membrane permeability on survival of hemodialysis patients |
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| المؤلفون: | Locatelli, Francesco, Martin-Malo, Alejandro, Hannedouche, Thierry, Loureiro, Alfredo, Papadimitriou, Menelaos, Wizemann, Volker, Jacobson, Stefan H., Czekalski, Stanislow, Ronco, Claudio, Vanholder, Raymond, Krzesinski, Jean-Marie |
| المصدر: | Journal of the American Society of Nephrology, 20, 645-654 (2009) |
| بيانات النشر: | American Society of Nephrology, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Human health sciences, Urology & nephrology, Sciences de la santé humaine, Urologie & néphrologie |
| الوصف: | The effect of high-flux hemodialysis membranes on patient survival has not been unequivocally determined. In this prospective, randomized clinical trial, we enrolled 738 incident hemodialysis patients, stratified them by serum albumin 4 and 4 g/dl, and assigned them to either low-flux or high-flux membranes. We followed patients for 3 to 7.5 yr. Kaplan-Meier survival analysis showed no significant difference between high-flux and low-flux membranes, and a Cox proportional hazards model concurred. Patients with serum albumin 4 g/dl had significantly higher survival rates in the high-flux group compared with the low-fluxgroup (P 0.032). In addition, a secondary analysis revealed that high-flux membranes may significantly improve survival of patients with diabetes. Among those with serum albumin 4 g/dl, slightly different effects among patients with and without diabetes suggested a potential interaction between diabetes status and low serum albumin in the reduction of risk conferred by high-flux membranes. In summary, we did not detect a significant survival benefit with either high-flux or low-flux membranes in the population overall, but the use of high-flux membranes conferred a significant survival benefit among patients with serum albumin 4 g/dl. The apparent survival benefit among patients who have diabetes and are treated with high-flux membranes requires confirmation given the post hoc nature of our analysis. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:1046-6673; urn:issn:1533-3450 |
| DOI: | 10.1681/ASN.2008060590 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/72149 |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess |
| رقم الأكسشن: | edsorb.72149 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1681/ASN.2008060590 |
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