مؤتمر
Polymorphic miRNA-target interactions : A Novel Source of Phenotypic Variation
| العنوان: | Polymorphic miRNA-target interactions : A Novel Source of Phenotypic Variation |
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| المؤلفون: | Georges, Michel, Clop, Alex, Marcq, Fabienne, Takeda, Haruko, Pirottin, Dimitri, Tordoir, Xavier, Hiard, Samuel, Bibé, B., Bouix, J., Caiment, Florian, Eychenne, F., Larzul, C., Laville, E., Meish, F., Milenkovic, D., Tobin, J., Charlier, Carole |
| المساهمون: | Systmod |
| المصدر: | Cold Spring Harbor Symposia on Quantitative Biology, 71, 343-350 (2006-06); Cold Spring Harbor Symposia on Quantitative Biology 2006, New York, United States [US], 2006 |
| بيانات النشر: | Cold Spring Harbor Laboratory Press, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | bioinformatics, Polymorphic, miRNA, target, interaction, phenotypic, Engineering, computing & technology, Computer science, Life sciences, Genetics & genetic processes, Ingénierie, informatique & technologie, Sciences informatiques, Sciences du vivant, Génétique & processus génétiques |
| الوصف: | Studying the muscular hypertrophy of Texel sheep by forward genetics, we have identified an A-to-G transition in the 3'UTRof the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and miR-206 that are highly expressed in skeletal muscle. This causes the down-regulation of this muscle-specific chalone and hence contributes to the muscular hypertrophyof Texel sheep. We demonstrate that polymorphisms which alter the content of putative miRNA target sites are commonin human and mice, and provide evidence that both conserved and nonconserved target sites are selectively constrained. Wespeculate that these polymorphisms might be important mediators of phenotypic variation including disease. To facilitatestudies along those lines, we have constructed a database (www.patrocles.org) listing putative polymorphic microRNA–targetinteractions. |
| نوع الوثيقة: | conference paper http://purl.org/coar/resource_type/c_5794 conferenceObject |
| اللغة: | English |
| Relation: | http://www.montefiore.ulg.ac.be/services/stochastic/pubs/2006/GCMTPTHBBCELLMMTC06 |
| DOI: | 10.1101/sqb.2006.71.056 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/90681 |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess |
| رقم الأكسشن: | edsorb.90681 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1101/sqb.2006.71.056 |
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