دورية أكاديمية
Interlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty.
| العنوان: | Interlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty. |
|---|---|
| المؤلفون: | Dehouck, P., Vander Heyden, Y., Smeyers-Verbeke, J., Massart, D. L., Marini Djang'Eing'A, Roland, Chiap, Patrice, Hubert, Philippe, Crommen, Jacques, Van de Wauw, W., De Beer, J., Cox, R., Mathieu, G., Reepmeyer, J. C., Voigt, B., Estevenon, O., Nicolas, Alain, Van Schepdael, A., Adams, E., Hoogmartens, J. |
| المصدر: | Journal of Chromatography. A, 1010 (1), 63-74 (2003) |
| بيانات النشر: | Elsevier Science, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Anti-Bacterial Agents/analysis, Chromatography, Liquid/methods, Erythromycin/analysis, Laboratories/organization & administration, Reproducibility of Results, Human health sciences, Pharmacy, pharmacology & toxicology, Sciences de la santé humaine, Pharmacie, pharmacologie & toxicologie |
| الوصف: | Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in one laboratory, the method was now validated in an interlaboratory study. Validation studies are commonly used to test the fitness of the analytical method prior to its use for routine quality testing. The data derived in the interlaboratory study can be used to make an uncertainty statement as well. The relationship between validation and uncertainty statement is not clear for many analysts and there is a need to show how the existing data, derived during validation, can be used in practice. Eight laboratories participated in this interlaboratory study. The set-up allowed the determination of the repeatability variance, s(2)r and the between-laboratory variance, s(2)L. Combination of s(2)r and s(2)L results in the reproducibility variance s(2)R. It has been shown how these data can be used in future by a single laboratory that wants to make an uncertainty statement concerning the same analysis. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501 article |
| اللغة: | English |
| Relation: | urn:issn:0021-9673; urn:issn:1873-3778 |
| DOI: | 10.1016/S0021-9673(03)01023-9 |
| URL الوصول: | https://orbi.uliege.be/handle/2268/9304 |
| حقوق: | restricted access http://purl.org/coar/access_right/c_16ec info:eu-repo/semantics/restrictedAccess |
| رقم الأكسشن: | edsorb.9304 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1016/S0021-9673(03)01023-9 |
|---|