دورية أكاديمية
A new series of hydrazide-hydrazones based 2-oxonicotinonitriles as antimicrobial agents: Design, synthesis and antimicrobial evaluation
| العنوان: | A new series of hydrazide-hydrazones based 2-oxonicotinonitriles as antimicrobial agents: Design, synthesis and antimicrobial evaluation |
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| المؤلفون: | El-Sayed, H.A., Moustafa, A. H., Abd El-Moneim, M., Awad, H. M., Esmat, A. |
| المصدر: | Afinidad. Revista de química teórica y aplicada; Vol. 75, Núm. 584 (2018) Afinidad; Vol. 75, Núm. 584 (2018) |
| Publication Status: | published |
| بيانات النشر: | Universitat Ramon Llull, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 2-Oxonicotinonitrile, alkylation, acid hydrazide, hydrazide-hydrazone, antimicrobial. |
| الوصف: | Regiospecific alkylation of 2-oxonicotinonitriles 1a,b with ethyl bromoacetate followed by hydrozinolysis afforded acetic acid hydrazides 3a,b. The latter compounds were condensed with a variety of carbonyl containing compounds to give the target compounds of hydrazones 4a,b, 5a,b, 6a-h and 7a,b. The antimicrobial activity of the new synthesized compounds do not showed activity against tested micro-organisms except compounds 4b, 5c, 5d and 6b showed moderate activity towards B. subtilus. |
| نوع الوثيقة: | article |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2339-9686 0001-9704 |
| Relation: | https://www.raco.cat/index.php/afinidad/article/view/347939/439126 |
| URL الوصول: | https://www.raco.cat/index.php/afinidad/article/view/347939 |
| رقم الأكسشن: | edsrac.347939 |
| قاعدة البيانات: | RACO (Revistes Catalanes amb Accés Obert) |
| تدمد: | 23399686 00019704 |
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