التفاصيل البيبلوغرافية
| العنوان: |
Intratumoral heterogeneity and clonal evolution in liver cancer |
| المؤلفون: |
Bojan Losic, Amanda J. Craig, Carlos Villacorta-Martin, Sebastiao N. Martins-Filho, Nicholas Akers, Xintong Chen, Mehmet E. Ahsen, Johann Felden, Ismail Labgaa, Delia DʹAvola, Kimaada Allett |
| المصدر: |
Nature, Nature Communications. 11(1):1-15 |
| سنة النشر: |
2020 |
| الوصف: |
Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multiple regions of liver cancer specimens to map spatio-temporal interactions between cancer and immune cells. We investigate how these interactions reflect intra-tumor heterogeneity (ITH) by correlating regional neo-epitope and viral antigen burden with the regional adaptive immune response. Regional expression of passenger mutations dominantly recruits adaptive responses as opposed to hepatitis B virus and cancer-testis antigens. We detect different clonal expansion of the adaptive immune system in distant regions of the same tumor. An ITH-based gene signature improves single-biopsy patient survival predictions and an expression survey of 38,553 single cells across 7 regions of 2 patients further reveals heterogeneity in liver cancer. These data quantify transcriptomic ITH and how the different components of the HCC ecosystem interact during cancer evolution. |
| نوع الوثيقة: |
redif-article |
| اللغة: |
English |
| DOI: |
10.1038/s41467-019-14050 |
| الإتاحة: |
https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-019-14050-z.html |
| رقم الأكسشن: |
edsrep.a.nat.natcom.v11y2020i1d10.1038.s41467.019.14050.z |
| قاعدة البيانات: |
RePEc |
