التفاصيل البيبلوغرافية
| العنوان: |
Non-human primate model of long-COVID identifies immune associates of hyperglycemia |
| المؤلفون: |
Clovis S. Palmer, Chrysostomos Perdios, Mohamed Abdel-Mohsen, Joseph Mudd, Prasun K. Datta, Nicholas J. Maness, Gabrielle Lehmicke, Nadia Golden, Linh Hellmers, Carol Coyne, Kristyn Moore Gr |
| المصدر: |
Nature, Nature Communications. 15(1):1-18 |
| سنة النشر: |
2024 |
| الوصف: |
Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys. Using this model, we identify a dysregulated blood chemokine signature during acute COVID-19 that correlates with elevated and persistent hyperglycemia four months post-infection. Hyperglycemia also correlates with liver glycogen levels, but there is no evidence of substantial long-term SARS-CoV-2 replication in the liver and pancreas. Finally, we report a favorable glycemic effect of the SARS-CoV-2 mRNA vaccine, administered on day 4 post-infection. Together, these data suggest that the African green monkey model exhibits important similarities to humans and can be utilized to assess therapeutic candidates to combat COVID-related metabolic defects. |
| نوع الوثيقة: |
redif-article |
| اللغة: |
English |
| DOI: |
10.1038/s41467-024-50339 |
| الإتاحة: |
https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-50339-4.html |
| رقم الأكسشن: |
edsrep.a.nat.natcom.v15y2024i1d10.1038.s41467.024.50339.4 |
| قاعدة البيانات: |
RePEc |
