التفاصيل البيبلوغرافية
| العنوان: |
The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NFκB activation |
| المؤلفون: |
Bart Tummers, Renske Goedemans, Laetitia P. L. Pelascini, Ekaterina S. Jordanova, Edith M. G. van Esch, Craig Meyers, Cornelis J. M. Melief, Judith M. Boer, Sjoerd H. van der Burg |
| المصدر: |
Nature, Nature Communications. 6(1):1-12 |
| سنة النشر: |
2015 |
| الوصف: |
High-risk human papillomaviruses (hrHPVs) infect keratinocytes and successfully evade host immunity despite the fact that keratinocytes are well equipped to respond to innate and adaptive immune signals. Using non-infected and freshly established or persistent hrHPV-infected keratinocytes we show that hrHPV impairs the acetylation of NFκB/RelA K310 in keratinocytes. As a consequence, keratinocytes display a decreased pro-inflammatory cytokine production and immune cell attraction in response to stimuli of the innate or adaptive immune pathways. HPV accomplishes this by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner. Restoration of NFκB/RelA acetylation by IFRD1 shRNA, cetuximab treatment or the HDAC1/3 inhibitor entinostat increases basal and induced cytokine expression. Similar observations are made in IFRD1-overexpressing HPV-induced cancer cells. Thus, our study reveals an EGFR–IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells. |
| نوع الوثيقة: |
redif-article |
| اللغة: |
English |
| DOI: |
10.1038/ncomms7537 |
| الإتاحة: |
https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms7537.html |
| رقم الأكسشن: |
edsrep.a.nat.natcom.v6y2015i1d10.1038.ncomms7537 |
| قاعدة البيانات: |
RePEc |
