التفاصيل البيبلوغرافية
| العنوان: |
Fundamental origins and limits for scaling a maternal morphogen gradient |
| المؤلفون: |
Feng He, Chuanxian Wei, Honggang Wu, David Cheung, Renjie Jiao, Jun Ma |
| المصدر: |
Nature, Nature Communications. 6(1):1-10 |
| سنة النشر: |
2015 |
| الوصف: |
Tissue expansion and patterning are integral to development; however, it is unknown quantitatively how a mother accumulates molecular resources to invest in the future of instructing robust embryonic patterning. Here we develop a model, Tissue Expansion-Modulated Maternal Morphogen Scaling (TEM3S), to study scaled anterior–posterior patterning in Drosophila embryos. Using both ovaries and embryos, we measure a core quantity of the model, the scaling power of the Bicoid (Bcd) morphogen gradient’s amplitude nA. We also evaluate directly model-derived predictions about Bcd gradient and patterning properties. Our results show that scaling of the Bcd gradient in the embryo originates from, and is constrained fundamentally by, a dynamic relationship between maternal tissue expansion and bcd gene copy number expansion in the ovary. This delicate connection between the two transitioning stages of a life cycle, stemming from a finite value of nA~3, underscores a key feature of developmental systems depicted by TEM3S. |
| نوع الوثيقة: |
redif-article |
| اللغة: |
English |
| DOI: |
10.1038/ncomms7679 |
| الإتاحة: |
https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms7679.html |
| رقم الأكسشن: |
edsrep.a.nat.natcom.v6y2015i1d10.1038.ncomms7679 |
| قاعدة البيانات: |
RePEc |
