التفاصيل البيبلوغرافية
| العنوان: |
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells |
| المؤلفون: |
Katsuhiro Sasaki, Kensuke Takada, Yuki Ohte, Hiroyuki Kondo, Hiroyuki Sorimachi, Keiji Tanaka, Yousuke Takahama, Shigeo Murata |
| المصدر: |
Nature, Nature Communications. 6(1):1-10 |
| سنة النشر: |
2015 |
| الوصف: |
Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major histocompatibility complex class I (MHC-I)-restricted T cells. Optimal positive selection of CD8+ T cells requires cortical thymic epithelial cells that express β5t-containing thymoproteasomes (tCPs). However, how tCPs govern positive selection is unclear. Here we show that the tCPs produce unique cleavage motifs in digested peptides and in MHC-I-associated peptides. Interestingly, MHC-I-associated peptides carrying these tCP-dependent motifs are enriched with low-affinity TCR ligands that efficiently induce the positive selection of functionally competent CD8+ T cells in antigen-specific TCR-transgenic models. These results suggest that tCPs contribute to the positive selection of CD8+ T cells by preferentially producing low-affinity TCR ligand peptides. |
| نوع الوثيقة: |
redif-article |
| اللغة: |
English |
| DOI: |
10.1038/ncomms8484 |
| الإتاحة: |
https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms8484.html |
| رقم الأكسشن: |
edsrep.a.nat.natcom.v6y2015i1d10.1038.ncomms8484 |
| قاعدة البيانات: |
RePEc |
