التفاصيل البيبلوغرافية
| العنوان: |
Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging |
| المؤلفون: |
Gabriel Oh, Sasha Ebrahimi, Matthew Carlucci, Aiping Zhang, Akhil Nair, Daniel E. Groot, Viviane Labrie, Peixin Jia, Edward S. Oh, Richie H. Jeremian, Miki Susic, Tenjin C. Shrestha, Marti |
| المصدر: |
Nature, Nature Communications. 9(1):1-11 |
| سنة النشر: |
2018 |
| الوصف: |
Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism’s deterioration. |
| نوع الوثيقة: |
redif-article |
| اللغة: |
English |
| DOI: |
10.1038/s41467-018-03073 |
| الإتاحة: |
https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-03073-7.html |
| رقم الأكسشن: |
edsrep.a.nat.natcom.v9y2018i1d10.1038.s41467.018.03073.7 |
| قاعدة البيانات: |
RePEc |
