التفاصيل البيبلوغرافية
| العنوان: |
Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance |
| المؤلفون: |
Jinfang Zhang, Xia Bu, Haizhen Wang, Yasheng Zhu, Yan Geng, Naoe Taira Nihira, Yuyong Tan, Yanpeng Ci, Fei Wu, Xiangpeng Dai, Jianping Guo, Yu-Han Huang, Caoqi Fan, Shancheng Ren, Yingha |
| المصدر: |
Nature, Nature. 553(7686):91-95 |
| سنة النشر: |
2018 |
| الوصف: |
Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment in mice improved survival when combined with CDK4/6 inhibitors. |
| نوع الوثيقة: |
redif-article |
| اللغة: |
English |
| DOI: |
10.1038/nature25015 |
| الإتاحة: |
https://ideas.repec.org/a/nat/nature/v553y2018i7686d10.1038_nature25015.html |
| رقم الأكسشن: |
edsrep.a.nat.nature.v553y2018i7686d10.1038.nature25015 |
| قاعدة البيانات: |
RePEc |
