كتاب إلكتروني
A new manganese biomonitoring concept for Mn exposure assessment based on Mn speciation
| العنوان: | A new manganese biomonitoring concept for Mn exposure assessment based on Mn speciation |
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| المؤلفون: | Michalke, B., Lucio, M., Kanawati, B., Berthele, A. |
| المصدر: | KIT Scientific PublishingOpenAIRE. |
| بيانات النشر: | KIT Scientific Publishing, 2014-10-13. |
| سنة النشر: | 2014 |
| وصف مادي: | 117-128 |
| مصطلحات موضوعية: | PSB, PSV, Public Health & Health Care Science, Social Sciences, Biomedical, manganese, speciation, serum, cerebrospinal fluid, biomarker, Nahrungsergänzungsmittel, Spurenelemente, Zink, Zytotoxizität, Genotoxizität, Kupfer |
| الوصف: | For humans Mn is an essential trace element, but at higher doses a neurotoxic metal. Chronic Mn exposure is affecting the central nervous system. Occupational Mn overexposure leads to an accumulation in the brain and has been shown to cause progressive, permanent, neurodegenerative damage with syndromes similar to idiopathic Parkinsonism. Mn is transported by an active mechanism across neural barriers (NB) finally into the brain, but to date modes of Mn neurotoxic action are poorly understood. This paper investigates the relevant Mn-carrier species which are responsible for a widely uncontrolled transport across NB. Mn speciation in paired serum/cerebrospinal fluid (CSF) samples was performed by size exclusion chromatography – inductively coupled plasma – dynamic reaction cell – mass spectrometry (SEC-ICP-DRC-MS) and capillary zone electrophoresis (CZE) coupled to ICP-DRC-MS in an 2D approach for clear identification. The Mn-species from the different sample types were interrelated, and correlation coefficients were calculated.In serum, protein-bound Mn-species like Mn-transferrin (Mn-Tf) had important influence on total Mn in serum if Mntotal was less than 1.5 µg/L, but above 1.6 µg/L the serum-Mntotal concentration was correlated with increasing Mn-citrate (Mn-Cit) concentration. Correlations between serum Mn species and CSF showed that Mntotal from CSF was correlated to Mn-Cit from serum above 1.6 µg/L Mntotal in serum.Statistical models discriminated the samples in two groups where CSF samples were either correlated to Mntotal and Mn-Cit (samples with serum Mntotal > 1.5 µg/L) or correlated to Mn-TF (samples with serum Mntotal < 1.5 µg/L).We conclude that elevated Mn-Citserum could be a valuable marker for increased total Mn in CSF (and brain). It could be used as a marker for elevated risk of Mn-dependent neurological disorders in occupational health. |
| نوع الوثيقة: | Chapter |
| اللغة: | English |
| ردمك: | 978-2-8218-5147-4 978-3-7315-0079-7 |
| Relation: | http://books.openedition.org/ksp/basictei/153; http://books.openedition.org/ksp/tei/153 |
| URL الوصول: | http://books.openedition.org/ksp/153 |
| حقوق: | CC BY-SA 3.0 |
| رقم الأكسشن: | edsrev.34398C33 |
| قاعدة البيانات: | Openedition.org |
| ردمك: | 9782821851474 9783731500797 |
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